A successful booster umbilical cord blood transplantation for a 10-year-old patient with beta-thalassemia major in India

Beta-thalassemia major is characterized by a genetic deficiency in synthesis of beta-globin chains, resulting in reduced levels of functional hemoglobin. It is characterized by anemia, hepatosplenomegaly, and iron overload due to repeated blood transfusion. Hematopoietic stem cell transplantation is...

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Autor principal:	Vijay Ramanan
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	beta-thalassemia major human leukocyte antigen-matched sibling umbilical cord blood transplantation Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/2fd643919be34829aa60d2e577eba8e4
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spelling	oai:doaj.org-article:2fd643919be34829aa60d2e577eba8e42021-11-12T10:08:28ZA successful booster umbilical cord blood transplantation for a 10-year-old patient with beta-thalassemia major in India0973-62471998-356510.4103/ajts.ajts_109_20https://doaj.org/article/2fd643919be34829aa60d2e577eba8e42021-01-01T00:00:00Zhttp://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=2;spage=250;epage=252;aulast=Ramananhttps://doaj.org/toc/0973-6247https://doaj.org/toc/1998-3565Beta-thalassemia major is characterized by a genetic deficiency in synthesis of beta-globin chains, resulting in reduced levels of functional hemoglobin. It is characterized by anemia, hepatosplenomegaly, and iron overload due to repeated blood transfusion. Hematopoietic stem cell transplantation is currently the only known curative treatment. We present a case of a 10-year-old girl with beta-thalassemia major who was successfully cured with allogeneic booster umbilical cord blood (UCB) transplantation with outcome data after 3 years of transplantation, in India. Postdiagnosis, she was on regular once-a-month blood transfusion until the age of 10 years, with no improvement. No serious adverse events occurred in the patient post-UCB transplantation. Chronic graft versus host disease was limited and was managed by medicines. Signs of primary graft rejection were also not seen.Vijay RamananWolters Kluwer Medknow Publicationsarticlebeta-thalassemia majorhuman leukocyte antigen-matched siblingumbilical cord blood transplantationDiseases of the blood and blood-forming organsRC633-647.5ENAsian Journal of Transfusion Science, Vol 15, Iss 2, Pp 250-252 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	beta-thalassemia major human leukocyte antigen-matched sibling umbilical cord blood transplantation Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	beta-thalassemia major human leukocyte antigen-matched sibling umbilical cord blood transplantation Diseases of the blood and blood-forming organs RC633-647.5 Vijay Ramanan A successful booster umbilical cord blood transplantation for a 10-year-old patient with beta-thalassemia major in India
description	Beta-thalassemia major is characterized by a genetic deficiency in synthesis of beta-globin chains, resulting in reduced levels of functional hemoglobin. It is characterized by anemia, hepatosplenomegaly, and iron overload due to repeated blood transfusion. Hematopoietic stem cell transplantation is currently the only known curative treatment. We present a case of a 10-year-old girl with beta-thalassemia major who was successfully cured with allogeneic booster umbilical cord blood (UCB) transplantation with outcome data after 3 years of transplantation, in India. Postdiagnosis, she was on regular once-a-month blood transfusion until the age of 10 years, with no improvement. No serious adverse events occurred in the patient post-UCB transplantation. Chronic graft versus host disease was limited and was managed by medicines. Signs of primary graft rejection were also not seen.
format	article
author	Vijay Ramanan
author_facet	Vijay Ramanan
author_sort	Vijay Ramanan
title	A successful booster umbilical cord blood transplantation for a 10-year-old patient with beta-thalassemia major in India
title_short	A successful booster umbilical cord blood transplantation for a 10-year-old patient with beta-thalassemia major in India
title_full	A successful booster umbilical cord blood transplantation for a 10-year-old patient with beta-thalassemia major in India
title_fullStr	A successful booster umbilical cord blood transplantation for a 10-year-old patient with beta-thalassemia major in India
title_full_unstemmed	A successful booster umbilical cord blood transplantation for a 10-year-old patient with beta-thalassemia major in India
title_sort	successful booster umbilical cord blood transplantation for a 10-year-old patient with beta-thalassemia major in india
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/2fd643919be34829aa60d2e577eba8e4
work_keys_str_mv	AT vijayramanan asuccessfulboosterumbilicalcordbloodtransplantationfora10yearoldpatientwithbetathalassemiamajorinindia AT vijayramanan successfulboosterumbilicalcordbloodtransplantationfora10yearoldpatientwithbetathalassemiamajorinindia
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A successful booster umbilical cord blood transplantation for a 10-year-old patient with beta-thalassemia major in India

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