Satiety behavior is regulated by ASI/ASH reciprocal antagonism

Abstract Appropriate decision-making is essential for ensuring survival; one such decision is whether to eat. Overall metabolic state and the safety of food are the two factors we examined using C. elegans to ask whether the metabolic state regulates neuronal activities and corresponding feeding beh...

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Autores principales:	Kristen C. Davis, Young-In Choi, Jeongho Kim, Young-Jai You
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2fd70b769a934a908dbae8e741991abf
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spelling	oai:doaj.org-article:2fd70b769a934a908dbae8e741991abf2021-12-02T15:07:44ZSatiety behavior is regulated by ASI/ASH reciprocal antagonism10.1038/s41598-018-24943-62045-2322https://doaj.org/article/2fd70b769a934a908dbae8e741991abf2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24943-6https://doaj.org/toc/2045-2322Abstract Appropriate decision-making is essential for ensuring survival; one such decision is whether to eat. Overall metabolic state and the safety of food are the two factors we examined using C. elegans to ask whether the metabolic state regulates neuronal activities and corresponding feeding behavior. We monitored the activity of sensory neurons that are activated by nutritious (or appetitive) stimuli (ASI) and aversive stimuli (ASH) in starved vs. well-fed worms during stimuli presentation. Starvation reduces ASH activity to aversive stimuli while increasing ASI activity to nutritious stimuli, showing the responsiveness of each neuron is modulated by overall metabolic state. When we monitored satiety quiescence behavior that reflects the overall metabolic state, ablation of ASI and ASH produce the opposite behavior, showing the two neurons interact to control the decision to eat or not. This circuit provides a simple approach to how neurons handle sensory conflict and reach a decision that is translated to behavior.Kristen C. DavisYoung-In ChoiJeongho KimYoung-Jai YouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kristen C. Davis Young-In Choi Jeongho Kim Young-Jai You Satiety behavior is regulated by ASI/ASH reciprocal antagonism
description	Abstract Appropriate decision-making is essential for ensuring survival; one such decision is whether to eat. Overall metabolic state and the safety of food are the two factors we examined using C. elegans to ask whether the metabolic state regulates neuronal activities and corresponding feeding behavior. We monitored the activity of sensory neurons that are activated by nutritious (or appetitive) stimuli (ASI) and aversive stimuli (ASH) in starved vs. well-fed worms during stimuli presentation. Starvation reduces ASH activity to aversive stimuli while increasing ASI activity to nutritious stimuli, showing the responsiveness of each neuron is modulated by overall metabolic state. When we monitored satiety quiescence behavior that reflects the overall metabolic state, ablation of ASI and ASH produce the opposite behavior, showing the two neurons interact to control the decision to eat or not. This circuit provides a simple approach to how neurons handle sensory conflict and reach a decision that is translated to behavior.
format	article
author	Kristen C. Davis Young-In Choi Jeongho Kim Young-Jai You
author_facet	Kristen C. Davis Young-In Choi Jeongho Kim Young-Jai You
author_sort	Kristen C. Davis
title	Satiety behavior is regulated by ASI/ASH reciprocal antagonism
title_short	Satiety behavior is regulated by ASI/ASH reciprocal antagonism
title_full	Satiety behavior is regulated by ASI/ASH reciprocal antagonism
title_fullStr	Satiety behavior is regulated by ASI/ASH reciprocal antagonism
title_full_unstemmed	Satiety behavior is regulated by ASI/ASH reciprocal antagonism
title_sort	satiety behavior is regulated by asi/ash reciprocal antagonism
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2fd70b769a934a908dbae8e741991abf
work_keys_str_mv	AT kristencdavis satietybehaviorisregulatedbyasiashreciprocalantagonism AT younginchoi satietybehaviorisregulatedbyasiashreciprocalantagonism AT jeonghokim satietybehaviorisregulatedbyasiashreciprocalantagonism AT youngjaiyou satietybehaviorisregulatedbyasiashreciprocalantagonism
_version_	1718388440362385408

Satiety behavior is regulated by ASI/ASH reciprocal antagonism

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