Platelet Function Testing and Genotyping for Tailoring Treatment in Complex PCI Patients

Dual antiplatelet therapy (DAPT), comprising aspirin and a P2Y12 receptor inhibitor, is considered the cornerstone of treatment in patients who have undergone percutaneous coronary intervention (PCI). Patients with complex PCI (C-PCI) constitute a special PCI subpopulation, characterized by increase...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Athanasios Moulias, Angeliki Papageorgiou, Dimitrios Alexopoulos
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/2fd8f0f78aa043a8bcd54b6fd753ba85
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2fd8f0f78aa043a8bcd54b6fd753ba85
record_format	dspace
spelling	oai:doaj.org-article:2fd8f0f78aa043a8bcd54b6fd753ba852021-12-04T16:04:52ZPlatelet Function Testing and Genotyping for Tailoring Treatment in Complex PCI Patients10.15420/usc.2020.331758-390X1758-3896https://doaj.org/article/2fd8f0f78aa043a8bcd54b6fd753ba852021-08-01T00:00:00Zhttps://www.uscjournal.com/articleindex/usc.2020.33https://doaj.org/toc/1758-3896https://doaj.org/toc/1758-390XDual antiplatelet therapy (DAPT), comprising aspirin and a P2Y12 receptor inhibitor, is considered the cornerstone of treatment in patients who have undergone percutaneous coronary intervention (PCI). Patients with complex PCI (C-PCI) constitute a special PCI subpopulation, characterized by increased ischemic risk. Identifying the optimal DAPT strategy is often challenging and remains controversial in this setting. In an attempt to balance ischemic and bleeding risks in C-PCI patients receiving DAPT, treatment individualization regarding potency and duration has evolved as a feasible approach. Platelet function testing and genotyping have been evaluated in several trials with conflicting and mostly neutral results. The aim of this review is to critically appreciate the role of these tools for antiplatelet treatment tailoring specifically in C-PCI patients. Because existing evidence is limited, dedicated future studies are warranted to elucidate the utility of platelet function testing and genotyping in C-PCI.Athanasios MouliasAngeliki PapageorgiouDimitrios AlexopoulosRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENUS Cardiology Review , Vol 15, Iss , Pp - (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Athanasios Moulias Angeliki Papageorgiou Dimitrios Alexopoulos Platelet Function Testing and Genotyping for Tailoring Treatment in Complex PCI Patients
description	Dual antiplatelet therapy (DAPT), comprising aspirin and a P2Y12 receptor inhibitor, is considered the cornerstone of treatment in patients who have undergone percutaneous coronary intervention (PCI). Patients with complex PCI (C-PCI) constitute a special PCI subpopulation, characterized by increased ischemic risk. Identifying the optimal DAPT strategy is often challenging and remains controversial in this setting. In an attempt to balance ischemic and bleeding risks in C-PCI patients receiving DAPT, treatment individualization regarding potency and duration has evolved as a feasible approach. Platelet function testing and genotyping have been evaluated in several trials with conflicting and mostly neutral results. The aim of this review is to critically appreciate the role of these tools for antiplatelet treatment tailoring specifically in C-PCI patients. Because existing evidence is limited, dedicated future studies are warranted to elucidate the utility of platelet function testing and genotyping in C-PCI.
format	article
author	Athanasios Moulias Angeliki Papageorgiou Dimitrios Alexopoulos
author_facet	Athanasios Moulias Angeliki Papageorgiou Dimitrios Alexopoulos
author_sort	Athanasios Moulias
title	Platelet Function Testing and Genotyping for Tailoring Treatment in Complex PCI Patients
title_short	Platelet Function Testing and Genotyping for Tailoring Treatment in Complex PCI Patients
title_full	Platelet Function Testing and Genotyping for Tailoring Treatment in Complex PCI Patients
title_fullStr	Platelet Function Testing and Genotyping for Tailoring Treatment in Complex PCI Patients
title_full_unstemmed	Platelet Function Testing and Genotyping for Tailoring Treatment in Complex PCI Patients
title_sort	platelet function testing and genotyping for tailoring treatment in complex pci patients
publisher	Radcliffe Medical Media
publishDate	2021
url	https://doaj.org/article/2fd8f0f78aa043a8bcd54b6fd753ba85
work_keys_str_mv	AT athanasiosmoulias plateletfunctiontestingandgenotypingfortailoringtreatmentincomplexpcipatients AT angelikipapageorgiou plateletfunctiontestingandgenotypingfortailoringtreatmentincomplexpcipatients AT dimitriosalexopoulos plateletfunctiontestingandgenotypingfortailoringtreatmentincomplexpcipatients
_version_	1718372664664391680

Platelet Function Testing and Genotyping for Tailoring Treatment in Complex PCI Patients

Ejemplares similares