Cut-off Values for Lower Limb Muscle Thickness to Detect Low Muscle Mass for Sarcopenia in Older Adults

Yoshihiro Fukumoto,1,2 Tome Ikezoe,2 Masashi Taniguchi,2 Yosuke Yamada,3 Shinichiro Sawano,4 Seigo Minani,5 Tsuyoshi Asai,6 Misaka Kimura,7,8 Noriaki Ichihashi2 1Department of Physical Medicine and Rehabilitation, Kansai Medical University, Hirakata, Japan; 2Human Health Sciences, Graduate School of...

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Autores principales:	Fukumoto Y, Ikezoe T, Taniguchi M, Yamada Y, Sawano S, Minani S, Asai T, Kimura M, Ichihashi N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	area under the curve bioelectric impedance skeletal muscle ultrasound Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/2fd953f95d0a48e493c2f07075b459b3
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spelling	oai:doaj.org-article:2fd953f95d0a48e493c2f07075b459b32021-12-02T14:52:07ZCut-off Values for Lower Limb Muscle Thickness to Detect Low Muscle Mass for Sarcopenia in Older Adults1178-1998https://doaj.org/article/2fd953f95d0a48e493c2f07075b459b32021-06-01T00:00:00Zhttps://www.dovepress.com/cut-off-values-for-lower-limb-muscle-thickness-to-detect-low-muscle-ma-peer-reviewed-fulltext-article-CIAhttps://doaj.org/toc/1178-1998Yoshihiro Fukumoto,1,2 Tome Ikezoe,2 Masashi Taniguchi,2 Yosuke Yamada,3 Shinichiro Sawano,4 Seigo Minani,5 Tsuyoshi Asai,6 Misaka Kimura,7,8 Noriaki Ichihashi2 1Department of Physical Medicine and Rehabilitation, Kansai Medical University, Hirakata, Japan; 2Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan; 3National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan; 4Rehabilitation Units, Shiga University of Medical Science Hospital, Otsu, Japan; 5Faculty of Rehabilitation, Osaka Kawasaki Rehabilitation University, Kaizuka, Japan; 6Faculty of Rehabilitation, Kobe Gakuin University, Kobe, Japan; 7Institute for Active Health, Kyoto University of Advanced Science, Kameoka, Japan; 8Graduate School of Nursing, Doshisha Women’s College of Liberal Arts, Kyotanabe, JapanCorrespondence: Yoshihiro FukumotoDepartment of Physical Medicine and Rehabilitation, Kansai Medical University, 2-5-1 Shin-Machi, Hirakata City, Osaka, Osaka, JapanTel +81-72-856-2307Fax +81-72-856-2150Email fukumoty@hirakata.kmu.ac.jpPurpose: Ultrasound-based prediction methods for the detection of low muscle mass for sarcopenia in older adults have been explored previously; however, the muscle that most accurately predicts it is unclear. This study aimed to clarify prediction accuracy and cut-off values for ultrasound-derived thigh and lower leg muscle thickness (MT) to detect low skeletal muscle mass index (SMI) in older adults and to estimate cut-off values based on two standard deviations (SD) below younger adult means for the corresponding muscles as an early detection tool for site-specific low muscle mass.Methods: This study included 204 community-dwelling older (64 males, 140 females, mean age: 75.4 years) and 59 younger (31 males, 28 females, mean age: 22.3 years) adults. The MT of the rectus femoris, vastus intermedius, gastrocnemius, and soleus muscles was measured using ultrasound; SMI was measured using bioelectrical impedance analysis.Results: The prevalence of a low SMI among older adults was 20.3% (n=13) for males and 21.4% (n=30) for females. The receiver operating characteristic analysis revealed that the total MT for the four muscles measured presented the highest area under the curve (AUC) value to predict low SMI for males (0.849) and females (0.776). The AUC value was the highest for the total MT of the gastrocnemius and soleus muscles for males and the gastrocnemius for females (0.836, 0.748; cut-off value: 5.67 cm, 1.42 cm, respectively). Muscle-specific differences between the low SMI-predicting and SD-based cut-off values were observed. The SD-based value for the rectus femoris (1.85 cm) was substantially higher than the low SMI-predicting value (1.51 cm) in males.Conclusion: Ultrasound measurement of lower leg muscles may be a simple, robust measure to detect low muscle mass for sarcopenia. Additionally, cut-off values for site-specific muscle mass loss may not always agree with those for whole-limb muscle mass loss.Keywords: area under the curve, bioelectric impedance, skeletal muscle, ultrasoundFukumoto YIkezoe TTaniguchi MYamada YSawano SMinani SAsai TKimura MIchihashi NDove Medical Pressarticlearea under the curvebioelectric impedanceskeletal muscleultrasoundGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 1215-1222 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	area under the curve bioelectric impedance skeletal muscle ultrasound Geriatrics RC952-954.6
spellingShingle	area under the curve bioelectric impedance skeletal muscle ultrasound Geriatrics RC952-954.6 Fukumoto Y Ikezoe T Taniguchi M Yamada Y Sawano S Minani S Asai T Kimura M Ichihashi N Cut-off Values for Lower Limb Muscle Thickness to Detect Low Muscle Mass for Sarcopenia in Older Adults
description	Yoshihiro Fukumoto,1,2 Tome Ikezoe,2 Masashi Taniguchi,2 Yosuke Yamada,3 Shinichiro Sawano,4 Seigo Minani,5 Tsuyoshi Asai,6 Misaka Kimura,7,8 Noriaki Ichihashi2 1Department of Physical Medicine and Rehabilitation, Kansai Medical University, Hirakata, Japan; 2Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan; 3National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan; 4Rehabilitation Units, Shiga University of Medical Science Hospital, Otsu, Japan; 5Faculty of Rehabilitation, Osaka Kawasaki Rehabilitation University, Kaizuka, Japan; 6Faculty of Rehabilitation, Kobe Gakuin University, Kobe, Japan; 7Institute for Active Health, Kyoto University of Advanced Science, Kameoka, Japan; 8Graduate School of Nursing, Doshisha Women’s College of Liberal Arts, Kyotanabe, JapanCorrespondence: Yoshihiro FukumotoDepartment of Physical Medicine and Rehabilitation, Kansai Medical University, 2-5-1 Shin-Machi, Hirakata City, Osaka, Osaka, JapanTel +81-72-856-2307Fax +81-72-856-2150Email fukumoty@hirakata.kmu.ac.jpPurpose: Ultrasound-based prediction methods for the detection of low muscle mass for sarcopenia in older adults have been explored previously; however, the muscle that most accurately predicts it is unclear. This study aimed to clarify prediction accuracy and cut-off values for ultrasound-derived thigh and lower leg muscle thickness (MT) to detect low skeletal muscle mass index (SMI) in older adults and to estimate cut-off values based on two standard deviations (SD) below younger adult means for the corresponding muscles as an early detection tool for site-specific low muscle mass.Methods: This study included 204 community-dwelling older (64 males, 140 females, mean age: 75.4 years) and 59 younger (31 males, 28 females, mean age: 22.3 years) adults. The MT of the rectus femoris, vastus intermedius, gastrocnemius, and soleus muscles was measured using ultrasound; SMI was measured using bioelectrical impedance analysis.Results: The prevalence of a low SMI among older adults was 20.3% (n=13) for males and 21.4% (n=30) for females. The receiver operating characteristic analysis revealed that the total MT for the four muscles measured presented the highest area under the curve (AUC) value to predict low SMI for males (0.849) and females (0.776). The AUC value was the highest for the total MT of the gastrocnemius and soleus muscles for males and the gastrocnemius for females (0.836, 0.748; cut-off value: 5.67 cm, 1.42 cm, respectively). Muscle-specific differences between the low SMI-predicting and SD-based cut-off values were observed. The SD-based value for the rectus femoris (1.85 cm) was substantially higher than the low SMI-predicting value (1.51 cm) in males.Conclusion: Ultrasound measurement of lower leg muscles may be a simple, robust measure to detect low muscle mass for sarcopenia. Additionally, cut-off values for site-specific muscle mass loss may not always agree with those for whole-limb muscle mass loss.Keywords: area under the curve, bioelectric impedance, skeletal muscle, ultrasound
format	article
author	Fukumoto Y Ikezoe T Taniguchi M Yamada Y Sawano S Minani S Asai T Kimura M Ichihashi N
author_facet	Fukumoto Y Ikezoe T Taniguchi M Yamada Y Sawano S Minani S Asai T Kimura M Ichihashi N
author_sort	Fukumoto Y
title	Cut-off Values for Lower Limb Muscle Thickness to Detect Low Muscle Mass for Sarcopenia in Older Adults
title_short	Cut-off Values for Lower Limb Muscle Thickness to Detect Low Muscle Mass for Sarcopenia in Older Adults
title_full	Cut-off Values for Lower Limb Muscle Thickness to Detect Low Muscle Mass for Sarcopenia in Older Adults
title_fullStr	Cut-off Values for Lower Limb Muscle Thickness to Detect Low Muscle Mass for Sarcopenia in Older Adults
title_full_unstemmed	Cut-off Values for Lower Limb Muscle Thickness to Detect Low Muscle Mass for Sarcopenia in Older Adults
title_sort	cut-off values for lower limb muscle thickness to detect low muscle mass for sarcopenia in older adults
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/2fd953f95d0a48e493c2f07075b459b3
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Cut-off Values for Lower Limb Muscle Thickness to Detect Low Muscle Mass for Sarcopenia in Older Adults

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