Estrogen leads to reversible hair cycle retardation through inducing premature catagen and maintaining telogen.

Estrogen dysregulation causes hair disorder. Clinical observations have demonstrated that estrogen raises the telogen/anagen ratio and inhibits hair shaft elongation of female scalp hair follicles. In spite of these clinical insights, the properties of estrogen on hair follicles are poorly dissected...

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Autores principales:	Hui-min Hu, Shou-bing Zhang, Xiao-hua Lei, Zhi-li Deng, Wei-xiang Guo, Zhi-fang Qiu, Shuang Liu, Xin-yue Wang, He Zhang, En-kui Duan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2fda3f65855b41f7b1b092b067c0d8f2
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spelling	oai:doaj.org-article:2fda3f65855b41f7b1b092b067c0d8f22021-11-18T07:13:23ZEstrogen leads to reversible hair cycle retardation through inducing premature catagen and maintaining telogen.1932-620310.1371/journal.pone.0040124https://doaj.org/article/2fda3f65855b41f7b1b092b067c0d8f22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22792225/?tool=EBIhttps://doaj.org/toc/1932-6203Estrogen dysregulation causes hair disorder. Clinical observations have demonstrated that estrogen raises the telogen/anagen ratio and inhibits hair shaft elongation of female scalp hair follicles. In spite of these clinical insights, the properties of estrogen on hair follicles are poorly dissected. In the present study, we show that estrogen induced apoptosis of precortex cells and caused premature catagen by up-regulation of TGF β2. Immediately after the premature catagen, the expression of anagen chalone BMP4 increased. The up-regulation of BMP4 may further function to prevent anagen transition and maintain telogen. Interestingly, the hair follicle stem cell niche was not destructed during these drastic structural changes caused by estrogen. Additionally, dermal papilla cells, the estrogen target cells in hair follicles, kept their signature gene expressions as well as their hair inductive potential after estrogen treatment. Retention of the characteristics of both hair follicle stem cells and dermal papilla cells determined the reversibility of the hair cycle suppression. These results indicated that estrogen causes reversible hair cycle retardation by inducing premature catagen and maintaining telogen.Hui-min HuShou-bing ZhangXiao-hua LeiZhi-li DengWei-xiang GuoZhi-fang QiuShuang LiuXin-yue WangHe ZhangEn-kui DuanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e40124 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hui-min Hu Shou-bing Zhang Xiao-hua Lei Zhi-li Deng Wei-xiang Guo Zhi-fang Qiu Shuang Liu Xin-yue Wang He Zhang En-kui Duan Estrogen leads to reversible hair cycle retardation through inducing premature catagen and maintaining telogen.
description	Estrogen dysregulation causes hair disorder. Clinical observations have demonstrated that estrogen raises the telogen/anagen ratio and inhibits hair shaft elongation of female scalp hair follicles. In spite of these clinical insights, the properties of estrogen on hair follicles are poorly dissected. In the present study, we show that estrogen induced apoptosis of precortex cells and caused premature catagen by up-regulation of TGF β2. Immediately after the premature catagen, the expression of anagen chalone BMP4 increased. The up-regulation of BMP4 may further function to prevent anagen transition and maintain telogen. Interestingly, the hair follicle stem cell niche was not destructed during these drastic structural changes caused by estrogen. Additionally, dermal papilla cells, the estrogen target cells in hair follicles, kept their signature gene expressions as well as their hair inductive potential after estrogen treatment. Retention of the characteristics of both hair follicle stem cells and dermal papilla cells determined the reversibility of the hair cycle suppression. These results indicated that estrogen causes reversible hair cycle retardation by inducing premature catagen and maintaining telogen.
format	article
author	Hui-min Hu Shou-bing Zhang Xiao-hua Lei Zhi-li Deng Wei-xiang Guo Zhi-fang Qiu Shuang Liu Xin-yue Wang He Zhang En-kui Duan
author_facet	Hui-min Hu Shou-bing Zhang Xiao-hua Lei Zhi-li Deng Wei-xiang Guo Zhi-fang Qiu Shuang Liu Xin-yue Wang He Zhang En-kui Duan
author_sort	Hui-min Hu
title	Estrogen leads to reversible hair cycle retardation through inducing premature catagen and maintaining telogen.
title_short	Estrogen leads to reversible hair cycle retardation through inducing premature catagen and maintaining telogen.
title_full	Estrogen leads to reversible hair cycle retardation through inducing premature catagen and maintaining telogen.
title_fullStr	Estrogen leads to reversible hair cycle retardation through inducing premature catagen and maintaining telogen.
title_full_unstemmed	Estrogen leads to reversible hair cycle retardation through inducing premature catagen and maintaining telogen.
title_sort	estrogen leads to reversible hair cycle retardation through inducing premature catagen and maintaining telogen.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/2fda3f65855b41f7b1b092b067c0d8f2
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_version_	1718423778626633728

Estrogen leads to reversible hair cycle retardation through inducing premature catagen and maintaining telogen.

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