Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine

Abstract Exposure to acute, damaging radiation may occur through a variety of events from cancer therapy and industrial accidents to terrorist attacks and military actions. Our understanding of how to protect individuals and mitigate the effects of radiation injury or Acute Radiation Syndrome (ARS)...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alexandra Crook, Aline De Lima Leite, Thomas Payne, Fatema Bhinderwala, Jade Woods, Vijay K. Singh, Robert Powers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2fdeff5b649d4262bcbde31ff8ad5fc1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2fdeff5b649d4262bcbde31ff8ad5fc1
record_format	dspace
spelling	oai:doaj.org-article:2fdeff5b649d4262bcbde31ff8ad5fc12021-12-02T15:22:56ZRadiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine10.1038/s41598-021-93401-72045-2322https://doaj.org/article/2fdeff5b649d4262bcbde31ff8ad5fc12021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93401-7https://doaj.org/toc/2045-2322Abstract Exposure to acute, damaging radiation may occur through a variety of events from cancer therapy and industrial accidents to terrorist attacks and military actions. Our understanding of how to protect individuals and mitigate the effects of radiation injury or Acute Radiation Syndrome (ARS) is still limited. There are only a few Food and Drug Administration-approved therapies for ARS; whereas, amifostine is limited to treating low dose (0.7–6 Gy) radiation poisoning arising from cancer radiotherapy. An early intervention is critical to treat ARS, which necessitates identifying diagnostic biomarkers to quickly characterize radiation exposure. Towards this end, a multiplatform metabolomics study was performed to comprehensively characterize the temporal changes in metabolite levels from mice and non-human primate serum samples following γ-irradiation. The metabolomic signature of amifostine was also evaluated in mice as a model for radioprotection. The NMR and mass spectrometry metabolomics analysis identified 23 dysregulated pathways resulting from the radiation exposure. These metabolomic alterations exhibited distinct trajectories within glucose metabolism, phospholipid biosynthesis, and nucleotide metabolism. A return to baseline levels with amifostine treatment occurred for these pathways within a week of radiation exposure. Together, our data suggests a unique physiological change that is independent of radiation dose or species. Furthermore, a metabolic signature of radioprotection was observed through the use of amifostine prophylaxis of ARS.Alexandra CrookAline De Lima LeiteThomas PayneFatema BhinderwalaJade WoodsVijay K. SinghRobert PowersNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexandra Crook Aline De Lima Leite Thomas Payne Fatema Bhinderwala Jade Woods Vijay K. Singh Robert Powers Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine
description	Abstract Exposure to acute, damaging radiation may occur through a variety of events from cancer therapy and industrial accidents to terrorist attacks and military actions. Our understanding of how to protect individuals and mitigate the effects of radiation injury or Acute Radiation Syndrome (ARS) is still limited. There are only a few Food and Drug Administration-approved therapies for ARS; whereas, amifostine is limited to treating low dose (0.7–6 Gy) radiation poisoning arising from cancer radiotherapy. An early intervention is critical to treat ARS, which necessitates identifying diagnostic biomarkers to quickly characterize radiation exposure. Towards this end, a multiplatform metabolomics study was performed to comprehensively characterize the temporal changes in metabolite levels from mice and non-human primate serum samples following γ-irradiation. The metabolomic signature of amifostine was also evaluated in mice as a model for radioprotection. The NMR and mass spectrometry metabolomics analysis identified 23 dysregulated pathways resulting from the radiation exposure. These metabolomic alterations exhibited distinct trajectories within glucose metabolism, phospholipid biosynthesis, and nucleotide metabolism. A return to baseline levels with amifostine treatment occurred for these pathways within a week of radiation exposure. Together, our data suggests a unique physiological change that is independent of radiation dose or species. Furthermore, a metabolic signature of radioprotection was observed through the use of amifostine prophylaxis of ARS.
format	article
author	Alexandra Crook Aline De Lima Leite Thomas Payne Fatema Bhinderwala Jade Woods Vijay K. Singh Robert Powers
author_facet	Alexandra Crook Aline De Lima Leite Thomas Payne Fatema Bhinderwala Jade Woods Vijay K. Singh Robert Powers
author_sort	Alexandra Crook
title	Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine
title_short	Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine
title_full	Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine
title_fullStr	Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine
title_full_unstemmed	Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine
title_sort	radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2fdeff5b649d4262bcbde31ff8ad5fc1
work_keys_str_mv	AT alexandracrook radiationexposureinducescrossspeciestemporalmetabolicchangesthataremitigatedinmicebyamifostine AT alinedelimaleite radiationexposureinducescrossspeciestemporalmetabolicchangesthataremitigatedinmicebyamifostine AT thomaspayne radiationexposureinducescrossspeciestemporalmetabolicchangesthataremitigatedinmicebyamifostine AT fatemabhinderwala radiationexposureinducescrossspeciestemporalmetabolicchangesthataremitigatedinmicebyamifostine AT jadewoods radiationexposureinducescrossspeciestemporalmetabolicchangesthataremitigatedinmicebyamifostine AT vijayksingh radiationexposureinducescrossspeciestemporalmetabolicchangesthataremitigatedinmicebyamifostine AT robertpowers radiationexposureinducescrossspeciestemporalmetabolicchangesthataremitigatedinmicebyamifostine
_version_	1718387375662432256

Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine

Ejemplares similares