Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine

Abstract Exposure to acute, damaging radiation may occur through a variety of events from cancer therapy and industrial accidents to terrorist attacks and military actions. Our understanding of how to protect individuals and mitigate the effects of radiation injury or Acute Radiation Syndrome (ARS)...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Alexandra Crook, Aline De Lima Leite, Thomas Payne, Fatema Bhinderwala, Jade Woods, Vijay K. Singh, Robert Powers
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/2fdeff5b649d4262bcbde31ff8ad5fc1
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:2fdeff5b649d4262bcbde31ff8ad5fc1
record_format dspace
spelling oai:doaj.org-article:2fdeff5b649d4262bcbde31ff8ad5fc12021-12-02T15:22:56ZRadiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine10.1038/s41598-021-93401-72045-2322https://doaj.org/article/2fdeff5b649d4262bcbde31ff8ad5fc12021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93401-7https://doaj.org/toc/2045-2322Abstract Exposure to acute, damaging radiation may occur through a variety of events from cancer therapy and industrial accidents to terrorist attacks and military actions. Our understanding of how to protect individuals and mitigate the effects of radiation injury or Acute Radiation Syndrome (ARS) is still limited. There are only a few Food and Drug Administration-approved therapies for ARS; whereas, amifostine is limited to treating low dose (0.7–6 Gy) radiation poisoning arising from cancer radiotherapy. An early intervention is critical to treat ARS, which necessitates identifying diagnostic biomarkers to quickly characterize radiation exposure. Towards this end, a multiplatform metabolomics study was performed to comprehensively characterize the temporal changes in metabolite levels from mice and non-human primate serum samples following γ-irradiation. The metabolomic signature of amifostine was also evaluated in mice as a model for radioprotection. The NMR and mass spectrometry metabolomics analysis identified 23 dysregulated pathways resulting from the radiation exposure. These metabolomic alterations exhibited distinct trajectories within glucose metabolism, phospholipid biosynthesis, and nucleotide metabolism. A return to baseline levels with amifostine treatment occurred for these pathways within a week of radiation exposure. Together, our data suggests a unique physiological change that is independent of radiation dose or species. Furthermore, a metabolic signature of radioprotection was observed through the use of amifostine prophylaxis of ARS.Alexandra CrookAline De Lima LeiteThomas PayneFatema BhinderwalaJade WoodsVijay K. SinghRobert PowersNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Alexandra Crook
Aline De Lima Leite
Thomas Payne
Fatema Bhinderwala
Jade Woods
Vijay K. Singh
Robert Powers
Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine
description Abstract Exposure to acute, damaging radiation may occur through a variety of events from cancer therapy and industrial accidents to terrorist attacks and military actions. Our understanding of how to protect individuals and mitigate the effects of radiation injury or Acute Radiation Syndrome (ARS) is still limited. There are only a few Food and Drug Administration-approved therapies for ARS; whereas, amifostine is limited to treating low dose (0.7–6 Gy) radiation poisoning arising from cancer radiotherapy. An early intervention is critical to treat ARS, which necessitates identifying diagnostic biomarkers to quickly characterize radiation exposure. Towards this end, a multiplatform metabolomics study was performed to comprehensively characterize the temporal changes in metabolite levels from mice and non-human primate serum samples following γ-irradiation. The metabolomic signature of amifostine was also evaluated in mice as a model for radioprotection. The NMR and mass spectrometry metabolomics analysis identified 23 dysregulated pathways resulting from the radiation exposure. These metabolomic alterations exhibited distinct trajectories within glucose metabolism, phospholipid biosynthesis, and nucleotide metabolism. A return to baseline levels with amifostine treatment occurred for these pathways within a week of radiation exposure. Together, our data suggests a unique physiological change that is independent of radiation dose or species. Furthermore, a metabolic signature of radioprotection was observed through the use of amifostine prophylaxis of ARS.
format article
author Alexandra Crook
Aline De Lima Leite
Thomas Payne
Fatema Bhinderwala
Jade Woods
Vijay K. Singh
Robert Powers
author_facet Alexandra Crook
Aline De Lima Leite
Thomas Payne
Fatema Bhinderwala
Jade Woods
Vijay K. Singh
Robert Powers
author_sort Alexandra Crook
title Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine
title_short Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine
title_full Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine
title_fullStr Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine
title_full_unstemmed Radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine
title_sort radiation exposure induces cross-species temporal metabolic changes that are mitigated in mice by amifostine
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2fdeff5b649d4262bcbde31ff8ad5fc1
work_keys_str_mv AT alexandracrook radiationexposureinducescrossspeciestemporalmetabolicchangesthataremitigatedinmicebyamifostine
AT alinedelimaleite radiationexposureinducescrossspeciestemporalmetabolicchangesthataremitigatedinmicebyamifostine
AT thomaspayne radiationexposureinducescrossspeciestemporalmetabolicchangesthataremitigatedinmicebyamifostine
AT fatemabhinderwala radiationexposureinducescrossspeciestemporalmetabolicchangesthataremitigatedinmicebyamifostine
AT jadewoods radiationexposureinducescrossspeciestemporalmetabolicchangesthataremitigatedinmicebyamifostine
AT vijayksingh radiationexposureinducescrossspeciestemporalmetabolicchangesthataremitigatedinmicebyamifostine
AT robertpowers radiationexposureinducescrossspeciestemporalmetabolicchangesthataremitigatedinmicebyamifostine
_version_ 1718387375662432256