Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system

Kostrzewski et al. introduce an in vitro microphysiological model of non-alcoholic steatohepatitis (NASH), consisting of co-cultured primary human liver cells. The authors characterised the transcriptomic, inflammatory and fibrotic phenotype of the model and show that major features of NASH can be r...

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Autores principales:	Tomasz Kostrzewski, Sophie Snow, Anya Lindström Battle, Samantha Peel, Zahida Ahmad, Jayati Basak, Manasa Surakala, Aurelie Bornot, Julia Lindgren, Maria Ryaboshapkina, Maryam Clausen, Daniel Lindén, Christian Maass, Lucy May Young, Adam Corrigan, Lorna Ewart, David Hughes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2fe033487d4045ff86e6fb36c7f3e8b7
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spelling	oai:doaj.org-article:2fe033487d4045ff86e6fb36c7f3e8b72021-12-02T17:25:42ZModelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system10.1038/s42003-021-02616-x2399-3642https://doaj.org/article/2fe033487d4045ff86e6fb36c7f3e8b72021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02616-xhttps://doaj.org/toc/2399-3642Kostrzewski et al. introduce an in vitro microphysiological model of non-alcoholic steatohepatitis (NASH), consisting of co-cultured primary human liver cells. The authors characterised the transcriptomic, inflammatory and fibrotic phenotype of the model and show that major features of NASH can be recapitulated and therapeutic interventions mimicked.Tomasz KostrzewskiSophie SnowAnya Lindström BattleSamantha PeelZahida AhmadJayati BasakManasa SurakalaAurelie BornotJulia LindgrenMaria RyaboshapkinaMaryam ClausenDaniel LindénChristian MaassLucy May YoungAdam CorriganLorna EwartDavid HughesNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Tomasz Kostrzewski Sophie Snow Anya Lindström Battle Samantha Peel Zahida Ahmad Jayati Basak Manasa Surakala Aurelie Bornot Julia Lindgren Maria Ryaboshapkina Maryam Clausen Daniel Lindén Christian Maass Lucy May Young Adam Corrigan Lorna Ewart David Hughes Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system
description	Kostrzewski et al. introduce an in vitro microphysiological model of non-alcoholic steatohepatitis (NASH), consisting of co-cultured primary human liver cells. The authors characterised the transcriptomic, inflammatory and fibrotic phenotype of the model and show that major features of NASH can be recapitulated and therapeutic interventions mimicked.
format	article
author	Tomasz Kostrzewski Sophie Snow Anya Lindström Battle Samantha Peel Zahida Ahmad Jayati Basak Manasa Surakala Aurelie Bornot Julia Lindgren Maria Ryaboshapkina Maryam Clausen Daniel Lindén Christian Maass Lucy May Young Adam Corrigan Lorna Ewart David Hughes
author_facet	Tomasz Kostrzewski Sophie Snow Anya Lindström Battle Samantha Peel Zahida Ahmad Jayati Basak Manasa Surakala Aurelie Bornot Julia Lindgren Maria Ryaboshapkina Maryam Clausen Daniel Lindén Christian Maass Lucy May Young Adam Corrigan Lorna Ewart David Hughes
author_sort	Tomasz Kostrzewski
title	Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system
title_short	Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system
title_full	Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system
title_fullStr	Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system
title_full_unstemmed	Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system
title_sort	modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2fe033487d4045ff86e6fb36c7f3e8b7
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Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system

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