Population-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus

Abstract To evaluate birth outcomes in women with hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM), we used insurance data of Taiwan to evaluate 11 adverse neonatal outcomes of infants born to women with HDP (N = 7775) and with both HDP and GDM (HDP/GDM) (N = 1946),...

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Autores principales:	Ya-Wen Lin, Ming-Hung Lin, Lee-Wen Pai, Jen-Wei Fang, Chih-Hsin Mou, Fung-Chang Sung, Ya-Ling Tzeng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2fe1bc5e19684538a52ffaf4bc000d47
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spelling	oai:doaj.org-article:2fe1bc5e19684538a52ffaf4bc000d472021-12-02T16:38:24ZPopulation-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus10.1038/s41598-021-96345-02045-2322https://doaj.org/article/2fe1bc5e19684538a52ffaf4bc000d472021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96345-0https://doaj.org/toc/2045-2322Abstract To evaluate birth outcomes in women with hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM), we used insurance data of Taiwan to evaluate 11 adverse neonatal outcomes of infants born to women with HDP (N = 7775) and with both HDP and GDM (HDP/GDM) (N = 1946), comparing to women with neither disorder (N = 19,442), matched by age. The impacts of preeclampsia/eclampsia were also evaluated. Results showed that Caesarean section delivery was near 1.7-fold greater in the HDP/GDM and HDP groups than in comparisons. The preterm delivery rates were more than threefold greater in HDP/GDM group and HDP group than in comparisons with adjusted odds ratios (aORs) of 4.84 (95% confidence interval (CI) 4.34–5.40) and 3.92 (95% CI 3.65–4.21), respectively, followed by jaundice (aORs 2.95 (95% CI 2.63–3.33) and 1.90 (95% CI 1.76–2.06)), and small gestation age (SGA) (aORs 6.57 (95% CI 5.56–7.75) and 5.81 (95% CI 5.15–6.55)). Incidence rates of birth trauma, patent ductus arteriosus, atrial septal defect, respiratory distress syndrome, and neonatal hypoglycemia were also higher in the HDP/GDM and HDP groups than in the comparison group. Most adverse outcomes increased further in women with preeclampsia or eclampsia. In conclusion, women with HDP are at elevated risks of adverse neonatal outcomes. Risks of most adverse outcomes increase further for women with both HDP and GDM. Preeclampsia or eclampsia may also contribute to these outcomes to higher risk levels. Every pregnant woman with these conditions deserves specialized prenatal care.Ya-Wen LinMing-Hung LinLee-Wen PaiJen-Wei FangChih-Hsin MouFung-Chang SungYa-Ling TzengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ya-Wen Lin Ming-Hung Lin Lee-Wen Pai Jen-Wei Fang Chih-Hsin Mou Fung-Chang Sung Ya-Ling Tzeng Population-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus
description	Abstract To evaluate birth outcomes in women with hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM), we used insurance data of Taiwan to evaluate 11 adverse neonatal outcomes of infants born to women with HDP (N = 7775) and with both HDP and GDM (HDP/GDM) (N = 1946), comparing to women with neither disorder (N = 19,442), matched by age. The impacts of preeclampsia/eclampsia were also evaluated. Results showed that Caesarean section delivery was near 1.7-fold greater in the HDP/GDM and HDP groups than in comparisons. The preterm delivery rates were more than threefold greater in HDP/GDM group and HDP group than in comparisons with adjusted odds ratios (aORs) of 4.84 (95% confidence interval (CI) 4.34–5.40) and 3.92 (95% CI 3.65–4.21), respectively, followed by jaundice (aORs 2.95 (95% CI 2.63–3.33) and 1.90 (95% CI 1.76–2.06)), and small gestation age (SGA) (aORs 6.57 (95% CI 5.56–7.75) and 5.81 (95% CI 5.15–6.55)). Incidence rates of birth trauma, patent ductus arteriosus, atrial septal defect, respiratory distress syndrome, and neonatal hypoglycemia were also higher in the HDP/GDM and HDP groups than in the comparison group. Most adverse outcomes increased further in women with preeclampsia or eclampsia. In conclusion, women with HDP are at elevated risks of adverse neonatal outcomes. Risks of most adverse outcomes increase further for women with both HDP and GDM. Preeclampsia or eclampsia may also contribute to these outcomes to higher risk levels. Every pregnant woman with these conditions deserves specialized prenatal care.
format	article
author	Ya-Wen Lin Ming-Hung Lin Lee-Wen Pai Jen-Wei Fang Chih-Hsin Mou Fung-Chang Sung Ya-Ling Tzeng
author_facet	Ya-Wen Lin Ming-Hung Lin Lee-Wen Pai Jen-Wei Fang Chih-Hsin Mou Fung-Chang Sung Ya-Ling Tzeng
author_sort	Ya-Wen Lin
title	Population-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus
title_short	Population-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus
title_full	Population-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus
title_fullStr	Population-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus
title_full_unstemmed	Population-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus
title_sort	population-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2fe1bc5e19684538a52ffaf4bc000d47
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Population-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus

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