Diet-independent remodeling of cellular membranes precedes seasonally changing body temperature in a hibernator.

Polyunsaturated fatty acids (PUFA) have a multitude of health effects. Their incorporation into membrane phospholipids (PL) is generally believed to depend directly on dietary influx. PL influence transmembrane protein activity and thus can compensate temperature effects; e.g. PL n-6 PUFA are though...

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Autores principales:	Walter Arnold, Thomas Ruf, Fredy Frey-Roos, Ute Bruns
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2fe30d885bc648248702cd72ddacea9a
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spelling	oai:doaj.org-article:2fe30d885bc648248702cd72ddacea9a2021-11-18T06:55:49ZDiet-independent remodeling of cellular membranes precedes seasonally changing body temperature in a hibernator.1932-620310.1371/journal.pone.0018641https://doaj.org/article/2fe30d885bc648248702cd72ddacea9a2011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21533242/?tool=EBIhttps://doaj.org/toc/1932-6203Polyunsaturated fatty acids (PUFA) have a multitude of health effects. Their incorporation into membrane phospholipids (PL) is generally believed to depend directly on dietary influx. PL influence transmembrane protein activity and thus can compensate temperature effects; e.g. PL n-6 PUFA are thought to stabilize heart function at low body temperature (T(b)), whereas long chain (>C18) n-3 PUFA may boost oxidative capacity. We found substantial remodeling of membranes in free-living alpine marmots which was largely independent of direct dietary supply. Organ PL n-6 PUFA and n-6 to n-3 ratios were highest at onset and end of hibernation after rapid increases during a brief transitional period prior to hibernation. In contrast, longer chain PL n-3 PUFA content was low at end of summer but maximal at end of hibernation. After termination of hibernation in spring, these changes in PL composition were rapidly reversed. Our results demonstrate selective trafficking of PUFA within the body, probably governed by a circannual endogenous rhythm, as hibernating marmots were in winter burrows isolated for seven months from food and external cues signaling the approaching spring. High concentrations of PL n-6 PUFA throughout hibernation are in line with their hypothesized function of boosting SERCA 2a activity at low T(b). Furthermore, we found increasing rate of rewarming from torpor during winter indicating increasing oxidative capacity that could be explained by the accumulation of long-chain PL n-3 PUFA. It may serve to minimize the time necessary for rewarming despite the increasing temperature range to be covered, because rewarming is a period of highest metabolic rate and hence production of reactive oxygen species. Considering the importance of PUFA for health our results may have important biomedical implications, as seasonal changes of T(b) and associated remodeling of membranes are not restricted to hibernators but presumably common among endothermic organisms.Walter ArnoldThomas RufFredy Frey-RoosUte BrunsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e18641 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Walter Arnold Thomas Ruf Fredy Frey-Roos Ute Bruns Diet-independent remodeling of cellular membranes precedes seasonally changing body temperature in a hibernator.
description	Polyunsaturated fatty acids (PUFA) have a multitude of health effects. Their incorporation into membrane phospholipids (PL) is generally believed to depend directly on dietary influx. PL influence transmembrane protein activity and thus can compensate temperature effects; e.g. PL n-6 PUFA are thought to stabilize heart function at low body temperature (T(b)), whereas long chain (>C18) n-3 PUFA may boost oxidative capacity. We found substantial remodeling of membranes in free-living alpine marmots which was largely independent of direct dietary supply. Organ PL n-6 PUFA and n-6 to n-3 ratios were highest at onset and end of hibernation after rapid increases during a brief transitional period prior to hibernation. In contrast, longer chain PL n-3 PUFA content was low at end of summer but maximal at end of hibernation. After termination of hibernation in spring, these changes in PL composition were rapidly reversed. Our results demonstrate selective trafficking of PUFA within the body, probably governed by a circannual endogenous rhythm, as hibernating marmots were in winter burrows isolated for seven months from food and external cues signaling the approaching spring. High concentrations of PL n-6 PUFA throughout hibernation are in line with their hypothesized function of boosting SERCA 2a activity at low T(b). Furthermore, we found increasing rate of rewarming from torpor during winter indicating increasing oxidative capacity that could be explained by the accumulation of long-chain PL n-3 PUFA. It may serve to minimize the time necessary for rewarming despite the increasing temperature range to be covered, because rewarming is a period of highest metabolic rate and hence production of reactive oxygen species. Considering the importance of PUFA for health our results may have important biomedical implications, as seasonal changes of T(b) and associated remodeling of membranes are not restricted to hibernators but presumably common among endothermic organisms.
format	article
author	Walter Arnold Thomas Ruf Fredy Frey-Roos Ute Bruns
author_facet	Walter Arnold Thomas Ruf Fredy Frey-Roos Ute Bruns
author_sort	Walter Arnold
title	Diet-independent remodeling of cellular membranes precedes seasonally changing body temperature in a hibernator.
title_short	Diet-independent remodeling of cellular membranes precedes seasonally changing body temperature in a hibernator.
title_full	Diet-independent remodeling of cellular membranes precedes seasonally changing body temperature in a hibernator.
title_fullStr	Diet-independent remodeling of cellular membranes precedes seasonally changing body temperature in a hibernator.
title_full_unstemmed	Diet-independent remodeling of cellular membranes precedes seasonally changing body temperature in a hibernator.
title_sort	diet-independent remodeling of cellular membranes precedes seasonally changing body temperature in a hibernator.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/2fe30d885bc648248702cd72ddacea9a
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Diet-independent remodeling of cellular membranes precedes seasonally changing body temperature in a hibernator.

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