Zn(II) binding causes interdomain changes in the structure and flexibility of the human prion protein

Zn(II) binding causes interdomain changes in the structure and flexibility of the human prion protein

Abstract The cellular prion protein (PrPC) is a mainly α-helical 208-residue protein located in the pre- and postsynaptic membranes. For unknown reasons, PrPC can undergo a structural transition into a toxic, β-sheet rich scrapie isoform (PrPSc) that is responsible for transmissible spongiform encep...

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Autores principales: Maciej Gielnik, Michał Taube, Lilia Zhukova, Igor Zhukov, Sebastian K. T. S. Wärmländer, Željko Svedružić, Wojciech M. Kwiatek, Astrid Gräslund, Maciej Kozak
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/2fe3416e0e5f40d4a4f38ea7f65014b5
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