MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload

Targeting damage to mitochondria has become an effective strategy antitumor therapies. Here, the authors report on nanoagents with upconversion nanoparticles as cores and photoacid-loaded MOFs as shells for NIR triggered Fenton reaction, acidification and calcium overload to provide synergistic mito...

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Autores principales:	Weier Bao, Ming Liu, Jiaqi Meng, Siyuan Liu, Shuang Wang, Rongrong Jia, Yugang Wang, Guanghui Ma, Wei Wei, Zhiyuan Tian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2fe3a85938ee463481d9452aebd686d4
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spelling	oai:doaj.org-article:2fe3a85938ee463481d9452aebd686d42021-11-08T11:06:05ZMOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload10.1038/s41467-021-26655-42041-1723https://doaj.org/article/2fe3a85938ee463481d9452aebd686d42021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26655-4https://doaj.org/toc/2041-1723Targeting damage to mitochondria has become an effective strategy antitumor therapies. Here, the authors report on nanoagents with upconversion nanoparticles as cores and photoacid-loaded MOFs as shells for NIR triggered Fenton reaction, acidification and calcium overload to provide synergistic mitochondrial damage.Weier BaoMing LiuJiaqi MengSiyuan LiuShuang WangRongrong JiaYugang WangGuanghui MaWei WeiZhiyuan TianNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weier Bao Ming Liu Jiaqi Meng Siyuan Liu Shuang Wang Rongrong Jia Yugang Wang Guanghui Ma Wei Wei Zhiyuan Tian MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload
description	Targeting damage to mitochondria has become an effective strategy antitumor therapies. Here, the authors report on nanoagents with upconversion nanoparticles as cores and photoacid-loaded MOFs as shells for NIR triggered Fenton reaction, acidification and calcium overload to provide synergistic mitochondrial damage.
format	article
author	Weier Bao Ming Liu Jiaqi Meng Siyuan Liu Shuang Wang Rongrong Jia Yugang Wang Guanghui Ma Wei Wei Zhiyuan Tian
author_facet	Weier Bao Ming Liu Jiaqi Meng Siyuan Liu Shuang Wang Rongrong Jia Yugang Wang Guanghui Ma Wei Wei Zhiyuan Tian
author_sort	Weier Bao
title	MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload
title_short	MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload
title_full	MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload
title_fullStr	MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload
title_full_unstemmed	MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload
title_sort	mofs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2fe3a85938ee463481d9452aebd686d4
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MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload

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