MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload

MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload

Targeting damage to mitochondria has become an effective strategy antitumor therapies. Here, the authors report on nanoagents with upconversion nanoparticles as cores and photoacid-loaded MOFs as shells for NIR triggered Fenton reaction, acidification and calcium overload to provide synergistic mito...

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Autores principales: Weier Bao, Ming Liu, Jiaqi Meng, Siyuan Liu, Shuang Wang, Rongrong Jia, Yugang Wang, Guanghui Ma, Wei Wei, Zhiyuan Tian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/2fe3a85938ee463481d9452aebd686d4
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