NON-INVASIVE TREATMENT OF MUSCLE INVASIVE BLADDER CANCER IN PATIENTS WITH DERANGED RENAL PROFILE

Objective: To determine the efficacy of trimodality therapy in patients with muscle invasive carcinoma of the bladder with deranged renal profile. Study Design: Quasi-experimental study. Place and Duration of Study: Oncology Department, Combined Military Hospital Rawalpindi over 14 months,...

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Autores principales:	Muhammad Adnan Zeb, Muhammad Sohaib Nadeem, Abdus Samad Saeed, Qurat ul Ain, Ujala Ali
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	concurrent chemo-radiation therapy deranged renal profile muscle invasive bladder cancer organ preservation Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2fe5b81aeda24a7181d0235a13b507da
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spelling	oai:doaj.org-article:2fe5b81aeda24a7181d0235a13b507da2021-11-26T03:26:56ZNON-INVASIVE TREATMENT OF MUSCLE INVASIVE BLADDER CANCER IN PATIENTS WITH DERANGED RENAL PROFILE0030-96482411-8842https://doaj.org/article/2fe5b81aeda24a7181d0235a13b507da2018-12-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2562/2100https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the efficacy of trimodality therapy in patients with muscle invasive carcinoma of the bladder with deranged renal profile. Study Design: Quasi-experimental study. Place and Duration of Study: Oncology Department, Combined Military Hospital Rawalpindi over 14 months, from Sep 2015 to Nov 2016. Patients and Methods: Forty patients (n=40) having histopathologically confirmed (urothelial) urinary bladder cancer, clinical stage II or III, aged 18 to 80 years, with Eastern Cooperative Oncology Group (ECOG) perfor-mance status ≤2 and having deranged renal functions were included in this study. After maximal transurethral resection of bladder tumour (TURBT), they received 4 courses of chemotherapy with mitomycin and 5 fluorou-racil, followed by concurrent chemoradiation using same chemotherapy received 50 Grays in 20 fractions. Response was assessed using RECIST criteria. Results: Efficacy; defined in terms of complete and partial response, was observed in 85% (n=34) of patients. Treatment efficacy was better in males as compared to females (90.6% vs. 62.55: p<0.05). Patients with better ECOG-PS (0-1) and early stage (2) responded well to treatment while response was almost same in different age groups, (p>0.05 in all cases). Thirty-seven patients were able to complete the full study protocol, 2 had severe mucositis and hand-foot syndrome while one patient died after septicaemia. Conclusion: Trimodality treatment with TURBT, chemotherapy and chemo-radiation is a feasible option for bladder preservation in muscle invasive bladder cancer patients with compromised renal functions if we use 5-fluorouracil and mitomycin chemotherapy.Muhammad Adnan ZebMuhammad Sohaib NadeemAbdus Samad SaeedQurat ul AinUjala AliArmy Medical College Rawalpindiarticleconcurrent chemo-radiation therapyderanged renal profilemuscle invasive bladder cancerorgan preservationMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 6, Pp 1636-1641 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	concurrent chemo-radiation therapy deranged renal profile muscle invasive bladder cancer organ preservation Medicine R Medicine (General) R5-920
spellingShingle	concurrent chemo-radiation therapy deranged renal profile muscle invasive bladder cancer organ preservation Medicine R Medicine (General) R5-920 Muhammad Adnan Zeb Muhammad Sohaib Nadeem Abdus Samad Saeed Qurat ul Ain Ujala Ali NON-INVASIVE TREATMENT OF MUSCLE INVASIVE BLADDER CANCER IN PATIENTS WITH DERANGED RENAL PROFILE
description	Objective: To determine the efficacy of trimodality therapy in patients with muscle invasive carcinoma of the bladder with deranged renal profile. Study Design: Quasi-experimental study. Place and Duration of Study: Oncology Department, Combined Military Hospital Rawalpindi over 14 months, from Sep 2015 to Nov 2016. Patients and Methods: Forty patients (n=40) having histopathologically confirmed (urothelial) urinary bladder cancer, clinical stage II or III, aged 18 to 80 years, with Eastern Cooperative Oncology Group (ECOG) perfor-mance status ≤2 and having deranged renal functions were included in this study. After maximal transurethral resection of bladder tumour (TURBT), they received 4 courses of chemotherapy with mitomycin and 5 fluorou-racil, followed by concurrent chemoradiation using same chemotherapy received 50 Grays in 20 fractions. Response was assessed using RECIST criteria. Results: Efficacy; defined in terms of complete and partial response, was observed in 85% (n=34) of patients. Treatment efficacy was better in males as compared to females (90.6% vs. 62.55: p<0.05). Patients with better ECOG-PS (0-1) and early stage (2) responded well to treatment while response was almost same in different age groups, (p>0.05 in all cases). Thirty-seven patients were able to complete the full study protocol, 2 had severe mucositis and hand-foot syndrome while one patient died after septicaemia. Conclusion: Trimodality treatment with TURBT, chemotherapy and chemo-radiation is a feasible option for bladder preservation in muscle invasive bladder cancer patients with compromised renal functions if we use 5-fluorouracil and mitomycin chemotherapy.
format	article
author	Muhammad Adnan Zeb Muhammad Sohaib Nadeem Abdus Samad Saeed Qurat ul Ain Ujala Ali
author_facet	Muhammad Adnan Zeb Muhammad Sohaib Nadeem Abdus Samad Saeed Qurat ul Ain Ujala Ali
author_sort	Muhammad Adnan Zeb
title	NON-INVASIVE TREATMENT OF MUSCLE INVASIVE BLADDER CANCER IN PATIENTS WITH DERANGED RENAL PROFILE
title_short	NON-INVASIVE TREATMENT OF MUSCLE INVASIVE BLADDER CANCER IN PATIENTS WITH DERANGED RENAL PROFILE
title_full	NON-INVASIVE TREATMENT OF MUSCLE INVASIVE BLADDER CANCER IN PATIENTS WITH DERANGED RENAL PROFILE
title_fullStr	NON-INVASIVE TREATMENT OF MUSCLE INVASIVE BLADDER CANCER IN PATIENTS WITH DERANGED RENAL PROFILE
title_full_unstemmed	NON-INVASIVE TREATMENT OF MUSCLE INVASIVE BLADDER CANCER IN PATIENTS WITH DERANGED RENAL PROFILE
title_sort	non-invasive treatment of muscle invasive bladder cancer in patients with deranged renal profile
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/2fe5b81aeda24a7181d0235a13b507da
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NON-INVASIVE TREATMENT OF MUSCLE INVASIVE BLADDER CANCER IN PATIENTS WITH DERANGED RENAL PROFILE

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