Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine

Abstract Increasing evidence points towards the role of mitochondrial functioning, energy metabolism, and oxidative stress in migraine. However not all previous research has been conclusive and some mitochondrial function/oxidative stress markers have not yet been examined. To this end, alpha-lipoic...

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Autores principales:	Elena C. Gross, Niveditha Putananickal, Anna-Lena Orsini, Deborah R. Vogt, Peter S. Sandor, Jean Schoenen, Dirk Fischer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2fe773f0b6cf45a4b8cb904040d65d23
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spelling	oai:doaj.org-article:2fe773f0b6cf45a4b8cb904040d65d232021-12-02T15:53:43ZMitochondrial function and oxidative stress markers in higher-frequency episodic migraine10.1038/s41598-021-84102-22045-2322https://doaj.org/article/2fe773f0b6cf45a4b8cb904040d65d232021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84102-2https://doaj.org/toc/2045-2322Abstract Increasing evidence points towards the role of mitochondrial functioning, energy metabolism, and oxidative stress in migraine. However not all previous research has been conclusive and some mitochondrial function/oxidative stress markers have not yet been examined. To this end, alpha-lipoic acid (ALA), total thiols, total plasma antioxidant capacity (TAC), lipid peroxide (PerOx), oxidised LDL (oxLDL), HbA1c and lactate were determined in the serum of 32 higher frequency episodic migraineurs (5–14 migraine days/ months, 19 with aura, 28 females) in this cross-sectional study. The majority of patients had abnormally low ALA and lactate levels (87.5% and 78.1%, respectively). 46.9% of the patients had abnormally high PerOx values, while for thiols and TAC over one third of patients had abnormally low values (31.2% and 37.5%, respectively). 21.9% of patients had abnormally low HbA1c and none had an HbA1c level above 5.6%. oxLDL was normal in all but one patient. This study provides further evidence for a role of oxidative stress and altered metabolism in migraine pathophysiology, which might represent a suitable therapeutic target. ALA, being too low in almost 90% of patients, might represent a potential biomarker for migraine. Further research is needed to replicate these results, in particular a comparison with a control group. This study is part of the trial registration: ClinicalTrials.gov: NCT03132233, registered on 27.04.2017, https://clinicaltrials.gov/ct2/show/NCT03132233 .Elena C. GrossNiveditha PutananickalAnna-Lena OrsiniDeborah R. VogtPeter S. SandorJean SchoenenDirk FischerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elena C. Gross Niveditha Putananickal Anna-Lena Orsini Deborah R. Vogt Peter S. Sandor Jean Schoenen Dirk Fischer Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine
description	Abstract Increasing evidence points towards the role of mitochondrial functioning, energy metabolism, and oxidative stress in migraine. However not all previous research has been conclusive and some mitochondrial function/oxidative stress markers have not yet been examined. To this end, alpha-lipoic acid (ALA), total thiols, total plasma antioxidant capacity (TAC), lipid peroxide (PerOx), oxidised LDL (oxLDL), HbA1c and lactate were determined in the serum of 32 higher frequency episodic migraineurs (5–14 migraine days/ months, 19 with aura, 28 females) in this cross-sectional study. The majority of patients had abnormally low ALA and lactate levels (87.5% and 78.1%, respectively). 46.9% of the patients had abnormally high PerOx values, while for thiols and TAC over one third of patients had abnormally low values (31.2% and 37.5%, respectively). 21.9% of patients had abnormally low HbA1c and none had an HbA1c level above 5.6%. oxLDL was normal in all but one patient. This study provides further evidence for a role of oxidative stress and altered metabolism in migraine pathophysiology, which might represent a suitable therapeutic target. ALA, being too low in almost 90% of patients, might represent a potential biomarker for migraine. Further research is needed to replicate these results, in particular a comparison with a control group. This study is part of the trial registration: ClinicalTrials.gov: NCT03132233, registered on 27.04.2017, https://clinicaltrials.gov/ct2/show/NCT03132233 .
format	article
author	Elena C. Gross Niveditha Putananickal Anna-Lena Orsini Deborah R. Vogt Peter S. Sandor Jean Schoenen Dirk Fischer
author_facet	Elena C. Gross Niveditha Putananickal Anna-Lena Orsini Deborah R. Vogt Peter S. Sandor Jean Schoenen Dirk Fischer
author_sort	Elena C. Gross
title	Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine
title_short	Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine
title_full	Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine
title_fullStr	Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine
title_full_unstemmed	Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine
title_sort	mitochondrial function and oxidative stress markers in higher-frequency episodic migraine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2fe773f0b6cf45a4b8cb904040d65d23
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Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine

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