Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease

Ozturk et al investigate the modulations in local field potentials induced by electrical stimulation of the subthalamic nucleus (STN) at therapeutic and nontherapeutic frequencies in Parkinson’s disease (PD) patients undergoing DBS surgery. They find evidence to suggest that high-frequency STN-DBS t...

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Autores principales:	Musa Ozturk, Ashwin Viswanathan, Sameer A. Sheth, Nuri F. Ince
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2fe9844fb7e24824ab4e11d4efe3b96e
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spelling	oai:doaj.org-article:2fe9844fb7e24824ab4e11d4efe3b96e2021-12-02T13:24:24ZElectroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease10.1038/s42003-021-01915-72399-3642https://doaj.org/article/2fe9844fb7e24824ab4e11d4efe3b96e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01915-7https://doaj.org/toc/2399-3642Ozturk et al investigate the modulations in local field potentials induced by electrical stimulation of the subthalamic nucleus (STN) at therapeutic and nontherapeutic frequencies in Parkinson’s disease (PD) patients undergoing DBS surgery. They find evidence to suggest that high-frequency STN-DBS tunes the neural oscillations to their healthy/treated state, similar to pharmacological treatment and thus could serve to recalibrate the dysfunctional circuitry generating PD symptoms.Musa OzturkAshwin ViswanathanSameer A. ShethNuri F. InceNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Musa Ozturk Ashwin Viswanathan Sameer A. Sheth Nuri F. Ince Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease
description	Ozturk et al investigate the modulations in local field potentials induced by electrical stimulation of the subthalamic nucleus (STN) at therapeutic and nontherapeutic frequencies in Parkinson’s disease (PD) patients undergoing DBS surgery. They find evidence to suggest that high-frequency STN-DBS tunes the neural oscillations to their healthy/treated state, similar to pharmacological treatment and thus could serve to recalibrate the dysfunctional circuitry generating PD symptoms.
format	article
author	Musa Ozturk Ashwin Viswanathan Sameer A. Sheth Nuri F. Ince
author_facet	Musa Ozturk Ashwin Viswanathan Sameer A. Sheth Nuri F. Ince
author_sort	Musa Ozturk
title	Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease
title_short	Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease
title_full	Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease
title_fullStr	Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease
title_full_unstemmed	Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease
title_sort	electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2fe9844fb7e24824ab4e11d4efe3b96e
work_keys_str_mv	AT musaozturk electroceuticallyinducedsubthalamichighfrequencyoscillationsandevokedcompoundactivitymayexplainthemechanismoftherapeuticstimulationinparkinsonsdisease AT ashwinviswanathan electroceuticallyinducedsubthalamichighfrequencyoscillationsandevokedcompoundactivitymayexplainthemechanismoftherapeuticstimulationinparkinsonsdisease AT sameerasheth electroceuticallyinducedsubthalamichighfrequencyoscillationsandevokedcompoundactivitymayexplainthemechanismoftherapeuticstimulationinparkinsonsdisease AT nurifince electroceuticallyinducedsubthalamichighfrequencyoscillationsandevokedcompoundactivitymayexplainthemechanismoftherapeuticstimulationinparkinsonsdisease
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Electroceutically induced subthalamic high-frequency oscillations and evoked compound activity may explain the mechanism of therapeutic stimulation in Parkinson’s disease

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