Prenatal Exposure to Heavy Metals Affects Gestational Age by Altering DNA Methylation Patterns

Environmental exposure is known to have toxic effects. Maternal environmental exposure not only affects mothers but also their fetuses in utero, which may interrupt their early development. Preterm birth, one of the outcomes of prenatal exposure, is a significant factor in lifelong health risks. To...

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Autores principales:	Eun Jung Koh, So Yeon Yu, Seung Hwan Kim, Ji Su Lee, Seung Yong Hwang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	heavy metals preterm birth DNA methylation prenatal exposome Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2fecb8952a2a4f99a3a7c1a0d80bf142
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id	oai:doaj.org-article:2fecb8952a2a4f99a3a7c1a0d80bf142
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spelling	oai:doaj.org-article:2fecb8952a2a4f99a3a7c1a0d80bf1422021-11-25T18:30:30ZPrenatal Exposure to Heavy Metals Affects Gestational Age by Altering DNA Methylation Patterns10.3390/nano111128712079-4991https://doaj.org/article/2fecb8952a2a4f99a3a7c1a0d80bf1422021-10-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/2871https://doaj.org/toc/2079-4991Environmental exposure is known to have toxic effects. Maternal environmental exposure not only affects mothers but also their fetuses in utero, which may interrupt their early development. Preterm birth, one of the outcomes of prenatal exposure, is a significant factor in lifelong health risks. To understand the effects of prenatal exposome on preterm birth, we studied the association between maternal and prenatal heavy metal exposure and gestational age, using resources from the MOthers’ and Children’s Environmental Health (MOCEH) study in South Korea. Additionally, a methylation assay was performed to analyze epigenetic mediation using genomic DNA derived from the cord blood of 384 participants in the MOCEH study. The results suggest that maternal cadmium exposure is associated with a decrease in gestational age through an alteration in DNA methylation at a specific CpG site, cg21010642. The CpG site was annotated to a gene involved in early embryonic development. Therefore, irregular methylation patterns at this site may contribute to premature birth by mediating irregular biological mechanisms.Eun Jung KohSo Yeon YuSeung Hwan KimJi Su LeeSeung Yong HwangMDPI AGarticleheavy metalspreterm birthDNA methylationprenatal exposomeChemistryQD1-999ENNanomaterials, Vol 11, Iss 2871, p 2871 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heavy metals preterm birth DNA methylation prenatal exposome Chemistry QD1-999
spellingShingle	heavy metals preterm birth DNA methylation prenatal exposome Chemistry QD1-999 Eun Jung Koh So Yeon Yu Seung Hwan Kim Ji Su Lee Seung Yong Hwang Prenatal Exposure to Heavy Metals Affects Gestational Age by Altering DNA Methylation Patterns
description	Environmental exposure is known to have toxic effects. Maternal environmental exposure not only affects mothers but also their fetuses in utero, which may interrupt their early development. Preterm birth, one of the outcomes of prenatal exposure, is a significant factor in lifelong health risks. To understand the effects of prenatal exposome on preterm birth, we studied the association between maternal and prenatal heavy metal exposure and gestational age, using resources from the MOthers’ and Children’s Environmental Health (MOCEH) study in South Korea. Additionally, a methylation assay was performed to analyze epigenetic mediation using genomic DNA derived from the cord blood of 384 participants in the MOCEH study. The results suggest that maternal cadmium exposure is associated with a decrease in gestational age through an alteration in DNA methylation at a specific CpG site, cg21010642. The CpG site was annotated to a gene involved in early embryonic development. Therefore, irregular methylation patterns at this site may contribute to premature birth by mediating irregular biological mechanisms.
format	article
author	Eun Jung Koh So Yeon Yu Seung Hwan Kim Ji Su Lee Seung Yong Hwang
author_facet	Eun Jung Koh So Yeon Yu Seung Hwan Kim Ji Su Lee Seung Yong Hwang
author_sort	Eun Jung Koh
title	Prenatal Exposure to Heavy Metals Affects Gestational Age by Altering DNA Methylation Patterns
title_short	Prenatal Exposure to Heavy Metals Affects Gestational Age by Altering DNA Methylation Patterns
title_full	Prenatal Exposure to Heavy Metals Affects Gestational Age by Altering DNA Methylation Patterns
title_fullStr	Prenatal Exposure to Heavy Metals Affects Gestational Age by Altering DNA Methylation Patterns
title_full_unstemmed	Prenatal Exposure to Heavy Metals Affects Gestational Age by Altering DNA Methylation Patterns
title_sort	prenatal exposure to heavy metals affects gestational age by altering dna methylation patterns
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2fecb8952a2a4f99a3a7c1a0d80bf142
work_keys_str_mv	AT eunjungkoh prenatalexposuretoheavymetalsaffectsgestationalagebyalteringdnamethylationpatterns AT soyeonyu prenatalexposuretoheavymetalsaffectsgestationalagebyalteringdnamethylationpatterns AT seunghwankim prenatalexposuretoheavymetalsaffectsgestationalagebyalteringdnamethylationpatterns AT jisulee prenatalexposuretoheavymetalsaffectsgestationalagebyalteringdnamethylationpatterns AT seungyonghwang prenatalexposuretoheavymetalsaffectsgestationalagebyalteringdnamethylationpatterns
_version_	1718411065742589952

Prenatal Exposure to Heavy Metals Affects Gestational Age by Altering DNA Methylation Patterns

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