Allosteric modulation of ghrelin receptor signaling by lipids

The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here authors demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effects and observe PIP2 and GM3 induced shifts of the...

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Autores principales:	Marjorie Damian, Maxime Louet, Antoniel Augusto Severo Gomes, Céline M’Kadmi, Séverine Denoyelle, Sonia Cantel, Sophie Mary, Paulo M. Bisch, Jean-Alain Fehrentz, Laurent J. Catoire, Nicolas Floquet, Jean-Louis Banères
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ff1774b14b842c1ba2707a2e704a84a
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spelling	oai:doaj.org-article:2ff1774b14b842c1ba2707a2e704a84a2021-12-02T17:14:22ZAllosteric modulation of ghrelin receptor signaling by lipids10.1038/s41467-021-23756-y2041-1723https://doaj.org/article/2ff1774b14b842c1ba2707a2e704a84a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23756-yhttps://doaj.org/toc/2041-1723The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here authors demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effects and observe PIP2 and GM3 induced shifts of the conformational equilibrium of GHSR away from its inactive state.Marjorie DamianMaxime LouetAntoniel Augusto Severo GomesCéline M’KadmiSéverine DenoyelleSonia CantelSophie MaryPaulo M. BischJean-Alain FehrentzLaurent J. CatoireNicolas FloquetJean-Louis BanèresNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marjorie Damian Maxime Louet Antoniel Augusto Severo Gomes Céline M’Kadmi Séverine Denoyelle Sonia Cantel Sophie Mary Paulo M. Bisch Jean-Alain Fehrentz Laurent J. Catoire Nicolas Floquet Jean-Louis Banères Allosteric modulation of ghrelin receptor signaling by lipids
description	The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here authors demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effects and observe PIP2 and GM3 induced shifts of the conformational equilibrium of GHSR away from its inactive state.
format	article
author	Marjorie Damian Maxime Louet Antoniel Augusto Severo Gomes Céline M’Kadmi Séverine Denoyelle Sonia Cantel Sophie Mary Paulo M. Bisch Jean-Alain Fehrentz Laurent J. Catoire Nicolas Floquet Jean-Louis Banères
author_facet	Marjorie Damian Maxime Louet Antoniel Augusto Severo Gomes Céline M’Kadmi Séverine Denoyelle Sonia Cantel Sophie Mary Paulo M. Bisch Jean-Alain Fehrentz Laurent J. Catoire Nicolas Floquet Jean-Louis Banères
author_sort	Marjorie Damian
title	Allosteric modulation of ghrelin receptor signaling by lipids
title_short	Allosteric modulation of ghrelin receptor signaling by lipids
title_full	Allosteric modulation of ghrelin receptor signaling by lipids
title_fullStr	Allosteric modulation of ghrelin receptor signaling by lipids
title_full_unstemmed	Allosteric modulation of ghrelin receptor signaling by lipids
title_sort	allosteric modulation of ghrelin receptor signaling by lipids
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2ff1774b14b842c1ba2707a2e704a84a
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Allosteric modulation of ghrelin receptor signaling by lipids

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