AHR signaling is induced by infection with coronaviruses

RNA viruses, such as Zika and Dengue, activate the aryl hydrocarbon receptor (AHR) signaling to restrict the antiviral response. Here, the authors report that coronaviruses also activate AHR signaling, potentially allowing them to escape the immune response, and show that AHR antagonism limits SARS-...

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Autores principales:	Federico Giovannoni, Zhaorong Li, Federico Remes-Lenicov, María E. Dávola, Mercedes Elizalde, Ana Paletta, Ali A. Ashkar, Karen L. Mossman, Andrea V. Dugour, Juan M. Figueroa, Andrea A. Barquero, Ana Ceballos, Cybele C. Garcia, Francisco J. Quintana
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ff68f600f9743548a72f6199e26d839
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spelling	oai:doaj.org-article:2ff68f600f9743548a72f6199e26d8392021-12-02T16:35:00ZAHR signaling is induced by infection with coronaviruses10.1038/s41467-021-25412-x2041-1723https://doaj.org/article/2ff68f600f9743548a72f6199e26d8392021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25412-xhttps://doaj.org/toc/2041-1723RNA viruses, such as Zika and Dengue, activate the aryl hydrocarbon receptor (AHR) signaling to restrict the antiviral response. Here, the authors report that coronaviruses also activate AHR signaling, potentially allowing them to escape the immune response, and show that AHR antagonism limits SARS-CoV-2 replication in vitro, suggesting that AHR could be targeted for antiviral therapy.Federico GiovannoniZhaorong LiFederico Remes-LenicovMaría E. DávolaMercedes ElizaldeAna PalettaAli A. AshkarKaren L. MossmanAndrea V. DugourJuan M. FigueroaAndrea A. BarqueroAna CeballosCybele C. GarciaFrancisco J. QuintanaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Federico Giovannoni Zhaorong Li Federico Remes-Lenicov María E. Dávola Mercedes Elizalde Ana Paletta Ali A. Ashkar Karen L. Mossman Andrea V. Dugour Juan M. Figueroa Andrea A. Barquero Ana Ceballos Cybele C. Garcia Francisco J. Quintana AHR signaling is induced by infection with coronaviruses
description	RNA viruses, such as Zika and Dengue, activate the aryl hydrocarbon receptor (AHR) signaling to restrict the antiviral response. Here, the authors report that coronaviruses also activate AHR signaling, potentially allowing them to escape the immune response, and show that AHR antagonism limits SARS-CoV-2 replication in vitro, suggesting that AHR could be targeted for antiviral therapy.
format	article
author	Federico Giovannoni Zhaorong Li Federico Remes-Lenicov María E. Dávola Mercedes Elizalde Ana Paletta Ali A. Ashkar Karen L. Mossman Andrea V. Dugour Juan M. Figueroa Andrea A. Barquero Ana Ceballos Cybele C. Garcia Francisco J. Quintana
author_facet	Federico Giovannoni Zhaorong Li Federico Remes-Lenicov María E. Dávola Mercedes Elizalde Ana Paletta Ali A. Ashkar Karen L. Mossman Andrea V. Dugour Juan M. Figueroa Andrea A. Barquero Ana Ceballos Cybele C. Garcia Francisco J. Quintana
author_sort	Federico Giovannoni
title	AHR signaling is induced by infection with coronaviruses
title_short	AHR signaling is induced by infection with coronaviruses
title_full	AHR signaling is induced by infection with coronaviruses
title_fullStr	AHR signaling is induced by infection with coronaviruses
title_full_unstemmed	AHR signaling is induced by infection with coronaviruses
title_sort	ahr signaling is induced by infection with coronaviruses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2ff68f600f9743548a72f6199e26d839
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AHR signaling is induced by infection with coronaviruses

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