A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells

FGF signaling through ERK is known to promote the differentiation of embryonic stem cells (ES cells). Here, the authors demonstrate that the lncRNA Trincr1 binds and represses TRIM71 in ES cells, leading to downregulation of SHCBP1 protein, the reduction of FGF/ERK signaling and the promotion of sel...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ya-Pu Li, Fei-Fei Duan, Yu-Ting Zhao, Kai-Li Gu, Le-Qi Liao, Huai-Bin Su, Jing Hao, Kun Zhang, Na Yang, Yangming Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ff6ac0c5bf84e1b8012f51786d35816
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2ff6ac0c5bf84e1b8012f51786d35816
record_format	dspace
spelling	oai:doaj.org-article:2ff6ac0c5bf84e1b8012f51786d358162021-12-02T16:51:00ZA TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells10.1038/s41467-019-08911-w2041-1723https://doaj.org/article/2ff6ac0c5bf84e1b8012f51786d358162019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08911-whttps://doaj.org/toc/2041-1723FGF signaling through ERK is known to promote the differentiation of embryonic stem cells (ES cells). Here, the authors demonstrate that the lncRNA Trincr1 binds and represses TRIM71 in ES cells, leading to downregulation of SHCBP1 protein, the reduction of FGF/ERK signaling and the promotion of self-renewal.Ya-Pu LiFei-Fei DuanYu-Ting ZhaoKai-Li GuLe-Qi LiaoHuai-Bin SuJing HaoKun ZhangNa YangYangming WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ya-Pu Li Fei-Fei Duan Yu-Ting Zhao Kai-Li Gu Le-Qi Liao Huai-Bin Su Jing Hao Kun Zhang Na Yang Yangming Wang A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells
description	FGF signaling through ERK is known to promote the differentiation of embryonic stem cells (ES cells). Here, the authors demonstrate that the lncRNA Trincr1 binds and represses TRIM71 in ES cells, leading to downregulation of SHCBP1 protein, the reduction of FGF/ERK signaling and the promotion of self-renewal.
format	article
author	Ya-Pu Li Fei-Fei Duan Yu-Ting Zhao Kai-Li Gu Le-Qi Liao Huai-Bin Su Jing Hao Kun Zhang Na Yang Yangming Wang
author_facet	Ya-Pu Li Fei-Fei Duan Yu-Ting Zhao Kai-Li Gu Le-Qi Liao Huai-Bin Su Jing Hao Kun Zhang Na Yang Yangming Wang
author_sort	Ya-Pu Li
title	A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells
title_short	A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells
title_full	A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells
title_fullStr	A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells
title_full_unstemmed	A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells
title_sort	trim71 binding long noncoding rna trincr1 represses fgf/erk signaling in embryonic stem cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2ff6ac0c5bf84e1b8012f51786d35816
work_keys_str_mv	AT yapuli atrim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT feifeiduan atrim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT yutingzhao atrim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT kailigu atrim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT leqiliao atrim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT huaibinsu atrim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT jinghao atrim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT kunzhang atrim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT nayang atrim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT yangmingwang atrim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT yapuli trim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT feifeiduan trim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT yutingzhao trim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT kailigu trim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT leqiliao trim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT huaibinsu trim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT jinghao trim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT kunzhang trim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT nayang trim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells AT yangmingwang trim71bindinglongnoncodingrnatrincr1repressesfgferksignalinginembryonicstemcells
_version_	1718382967940710400

A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells

Ejemplares similares