A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells

A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells

FGF signaling through ERK is known to promote the differentiation of embryonic stem cells (ES cells). Here, the authors demonstrate that the lncRNA Trincr1 binds and represses TRIM71 in ES cells, leading to downregulation of SHCBP1 protein, the reduction of FGF/ERK signaling and the promotion of sel...

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Autores principales: Ya-Pu Li, Fei-Fei Duan, Yu-Ting Zhao, Kai-Li Gu, Le-Qi Liao, Huai-Bin Su, Jing Hao, Kun Zhang, Na Yang, Yangming Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/2ff6ac0c5bf84e1b8012f51786d35816
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