Revisiting the multiple roles of T-cadherin in health and disease

As a non-canonical member of cadherin superfamily, T-cadherin was initially described as a molecule involved in homophilic recognition in the nervous and vascular systems. The ensuing decades clearly demonstrated that T-cadherin is a remarkably multifunctional molecule. It was validated as a bona fi...

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Autores principales:	K.A. Rubina, E.V. Semina, N.I. Kalinina, V.Yu. Sysoeva, A.V. Balatskiy, V.A. Tkachuk
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	T-cadherin Adiponectin Adiponectin receptors Metabolic disorders Cardiovascular diseases Cytology QH573-671
Acceso en línea:	https://doaj.org/article/2ff85bb3daa74bae9c4f85d078e9a859
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id	oai:doaj.org-article:2ff85bb3daa74bae9c4f85d078e9a859
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spelling	oai:doaj.org-article:2ff85bb3daa74bae9c4f85d078e9a8592021-11-18T04:43:21ZRevisiting the multiple roles of T-cadherin in health and disease0171-933510.1016/j.ejcb.2021.151183https://doaj.org/article/2ff85bb3daa74bae9c4f85d078e9a8592021-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0171933521000340https://doaj.org/toc/0171-9335As a non-canonical member of cadherin superfamily, T-cadherin was initially described as a molecule involved in homophilic recognition in the nervous and vascular systems. The ensuing decades clearly demonstrated that T-cadherin is a remarkably multifunctional molecule. It was validated as a bona fide receptor for both: LDL exerting adverse atherogenic action and adiponectin mediating many protective metabolic and cardiovascular effects. Motivated by the latest progress and accumulated data unmasking important roles of T-cadherin in blood vessel function and tissue regeneration, here we revisit the original function of T-cadherin as a guidance receptor for the growing axons and blood vessels, consider the recent data on T-cadherin-induced exosomes’ biogenesis and their role in myocardial regeneration and revascularization. The review expands upon T-cadherin contribution to mesenchymal stem/stromal cell compartment in adipose tissue. We also dwell upon T-cadherin polymorphisms (SNP) and their possible therapeutic applications. Furthermore, we scrutinize the molecular hub of insulin and adiponectin receptors (AdipoR1 and AdipoR2) conveying signals to their downstream targets in quest for defining a putative place of T-cadherin in this molecular circuitry.K.A. RubinaE.V. SeminaN.I. KalininaV.Yu. SysoevaA.V. BalatskiyV.A. TkachukElsevierarticleT-cadherinAdiponectinAdiponectin receptorsMetabolic disordersCardiovascular diseasesCytologyQH573-671ENEuropean Journal of Cell Biology, Vol 100, Iss 7, Pp 151183- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	T-cadherin Adiponectin Adiponectin receptors Metabolic disorders Cardiovascular diseases Cytology QH573-671
spellingShingle	T-cadherin Adiponectin Adiponectin receptors Metabolic disorders Cardiovascular diseases Cytology QH573-671 K.A. Rubina E.V. Semina N.I. Kalinina V.Yu. Sysoeva A.V. Balatskiy V.A. Tkachuk Revisiting the multiple roles of T-cadherin in health and disease
description	As a non-canonical member of cadherin superfamily, T-cadherin was initially described as a molecule involved in homophilic recognition in the nervous and vascular systems. The ensuing decades clearly demonstrated that T-cadherin is a remarkably multifunctional molecule. It was validated as a bona fide receptor for both: LDL exerting adverse atherogenic action and adiponectin mediating many protective metabolic and cardiovascular effects. Motivated by the latest progress and accumulated data unmasking important roles of T-cadherin in blood vessel function and tissue regeneration, here we revisit the original function of T-cadherin as a guidance receptor for the growing axons and blood vessels, consider the recent data on T-cadherin-induced exosomes’ biogenesis and their role in myocardial regeneration and revascularization. The review expands upon T-cadherin contribution to mesenchymal stem/stromal cell compartment in adipose tissue. We also dwell upon T-cadherin polymorphisms (SNP) and their possible therapeutic applications. Furthermore, we scrutinize the molecular hub of insulin and adiponectin receptors (AdipoR1 and AdipoR2) conveying signals to their downstream targets in quest for defining a putative place of T-cadherin in this molecular circuitry.
format	article
author	K.A. Rubina E.V. Semina N.I. Kalinina V.Yu. Sysoeva A.V. Balatskiy V.A. Tkachuk
author_facet	K.A. Rubina E.V. Semina N.I. Kalinina V.Yu. Sysoeva A.V. Balatskiy V.A. Tkachuk
author_sort	K.A. Rubina
title	Revisiting the multiple roles of T-cadherin in health and disease
title_short	Revisiting the multiple roles of T-cadherin in health and disease
title_full	Revisiting the multiple roles of T-cadherin in health and disease
title_fullStr	Revisiting the multiple roles of T-cadherin in health and disease
title_full_unstemmed	Revisiting the multiple roles of T-cadherin in health and disease
title_sort	revisiting the multiple roles of t-cadherin in health and disease
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2ff85bb3daa74bae9c4f85d078e9a859
work_keys_str_mv	AT karubina revisitingthemultiplerolesoftcadherininhealthanddisease AT evsemina revisitingthemultiplerolesoftcadherininhealthanddisease AT nikalinina revisitingthemultiplerolesoftcadherininhealthanddisease AT vyusysoeva revisitingthemultiplerolesoftcadherininhealthanddisease AT avbalatskiy revisitingthemultiplerolesoftcadherininhealthanddisease AT vatkachuk revisitingthemultiplerolesoftcadherininhealthanddisease
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Revisiting the multiple roles of T-cadherin in health and disease

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