Detection of pathological mechano-acoustic signatures using precision accelerometer contact microphones in patients with pulmonary disorders

Abstract Monitoring pathological mechano-acoustic signals emanating from the lungs is critical for timely and cost-effective healthcare delivery. Adventitious lung sounds including crackles, wheezes, rhonchi, bronchial breath sounds, stridor or pleural rub and abnormal breathing patterns function as...

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Autores principales:	Pranav Gupta, Haoran Wen, Lorenzo Di Francesco, Farrokh Ayazi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2ffd02e57e1a48e9a432fe4d2a191086
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spelling	oai:doaj.org-article:2ffd02e57e1a48e9a432fe4d2a1910862021-12-02T16:32:08ZDetection of pathological mechano-acoustic signatures using precision accelerometer contact microphones in patients with pulmonary disorders10.1038/s41598-021-92666-22045-2322https://doaj.org/article/2ffd02e57e1a48e9a432fe4d2a1910862021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92666-2https://doaj.org/toc/2045-2322Abstract Monitoring pathological mechano-acoustic signals emanating from the lungs is critical for timely and cost-effective healthcare delivery. Adventitious lung sounds including crackles, wheezes, rhonchi, bronchial breath sounds, stridor or pleural rub and abnormal breathing patterns function as essential clinical biomarkers for the early identification, accurate diagnosis and monitoring of pulmonary disorders. Here, we present a wearable sensor module comprising of a hermetically encapsulated, high precision accelerometer contact microphone (ACM) which enables both episodic and longitudinal assessment of lung sounds, breathing patterns and respiratory rates using a single integrated sensor. This enhanced ACM sensor leverages a nano-gap transduction mechanism to achieve high sensitivity to weak high frequency vibrations occurring on the surface of the skin due to underlying lung pathologies. The performance of the ACM sensor was compared to recordings from a state-of-art digital stethoscope, and the efficacy of the developed system is demonstrated by conducting an exploratory research study aimed at recording pathological mechano-acoustic signals from hospitalized patients with a chronic obstructive pulmonary disease (COPD) exacerbation, pneumonia, and acute decompensated heart failure. This unobtrusive wearable system can enable both episodic and longitudinal evaluation of lung sounds that allow for the early detection and/or ongoing monitoring of pulmonary disease.Pranav GuptaHaoran WenLorenzo Di FrancescoFarrokh AyaziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pranav Gupta Haoran Wen Lorenzo Di Francesco Farrokh Ayazi Detection of pathological mechano-acoustic signatures using precision accelerometer contact microphones in patients with pulmonary disorders
description	Abstract Monitoring pathological mechano-acoustic signals emanating from the lungs is critical for timely and cost-effective healthcare delivery. Adventitious lung sounds including crackles, wheezes, rhonchi, bronchial breath sounds, stridor or pleural rub and abnormal breathing patterns function as essential clinical biomarkers for the early identification, accurate diagnosis and monitoring of pulmonary disorders. Here, we present a wearable sensor module comprising of a hermetically encapsulated, high precision accelerometer contact microphone (ACM) which enables both episodic and longitudinal assessment of lung sounds, breathing patterns and respiratory rates using a single integrated sensor. This enhanced ACM sensor leverages a nano-gap transduction mechanism to achieve high sensitivity to weak high frequency vibrations occurring on the surface of the skin due to underlying lung pathologies. The performance of the ACM sensor was compared to recordings from a state-of-art digital stethoscope, and the efficacy of the developed system is demonstrated by conducting an exploratory research study aimed at recording pathological mechano-acoustic signals from hospitalized patients with a chronic obstructive pulmonary disease (COPD) exacerbation, pneumonia, and acute decompensated heart failure. This unobtrusive wearable system can enable both episodic and longitudinal evaluation of lung sounds that allow for the early detection and/or ongoing monitoring of pulmonary disease.
format	article
author	Pranav Gupta Haoran Wen Lorenzo Di Francesco Farrokh Ayazi
author_facet	Pranav Gupta Haoran Wen Lorenzo Di Francesco Farrokh Ayazi
author_sort	Pranav Gupta
title	Detection of pathological mechano-acoustic signatures using precision accelerometer contact microphones in patients with pulmonary disorders
title_short	Detection of pathological mechano-acoustic signatures using precision accelerometer contact microphones in patients with pulmonary disorders
title_full	Detection of pathological mechano-acoustic signatures using precision accelerometer contact microphones in patients with pulmonary disorders
title_fullStr	Detection of pathological mechano-acoustic signatures using precision accelerometer contact microphones in patients with pulmonary disorders
title_full_unstemmed	Detection of pathological mechano-acoustic signatures using precision accelerometer contact microphones in patients with pulmonary disorders
title_sort	detection of pathological mechano-acoustic signatures using precision accelerometer contact microphones in patients with pulmonary disorders
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2ffd02e57e1a48e9a432fe4d2a191086
work_keys_str_mv	AT pranavgupta detectionofpathologicalmechanoacousticsignaturesusingprecisionaccelerometercontactmicrophonesinpatientswithpulmonarydisorders AT haoranwen detectionofpathologicalmechanoacousticsignaturesusingprecisionaccelerometercontactmicrophonesinpatientswithpulmonarydisorders AT lorenzodifrancesco detectionofpathologicalmechanoacousticsignaturesusingprecisionaccelerometercontactmicrophonesinpatientswithpulmonarydisorders AT farrokhayazi detectionofpathologicalmechanoacousticsignaturesusingprecisionaccelerometercontactmicrophonesinpatientswithpulmonarydisorders
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Detection of pathological mechano-acoustic signatures using precision accelerometer contact microphones in patients with pulmonary disorders

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