Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration
Abstract While there has been significant progress in the development of rapid COVID-19 diagnostics, as the pandemic unfolds, new challenges have emerged, including whether these technologies can reliably detect the more infectious variants of concern and be viably deployed in non-clinical settings...
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Nature Portfolio
2021
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oai:doaj.org-article:30016094be9f470888a58161d2407fd52021-12-02T16:14:16ZMultidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration10.1038/s41598-021-94055-12045-2322https://doaj.org/article/30016094be9f470888a58161d2407fd52021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94055-1https://doaj.org/toc/2045-2322Abstract While there has been significant progress in the development of rapid COVID-19 diagnostics, as the pandemic unfolds, new challenges have emerged, including whether these technologies can reliably detect the more infectious variants of concern and be viably deployed in non-clinical settings as “self-tests”. Multidisciplinary evaluation of the Abbott BinaxNOW COVID-19 Ag Card (BinaxNOW, a widely used rapid antigen test, included limit of detection, variant detection, test performance across different age-groups, and usability with self/caregiver-administration. While BinaxNOW detected the highly infectious variants, B.1.1.7 (Alpha) first identified in the UK, B.1.351 (Beta) first identified in South Africa, P.1 (Gamma) first identified in Brazil, B.1.617.2 (Delta) first identified in India and B.1.2, a non-VOC, test sensitivity decreased with decreasing viral loads. Moreover, BinaxNOW sensitivity trended lower when devices were performed by patients/caregivers themselves compared to trained clinical staff, despite universally high usability assessments following self/caregiver-administration among different age groups. Overall, these data indicate that while BinaxNOW accurately detects the new viral variants, as rapid COVID-19 tests enter the home, their already lower sensitivities compared to RT-PCR may decrease even more due to user error.Jennifer K. FredianiJoshua M. LevyAnuradha RaoLeda BassitJanet FigueroaMiriam B. VosAnna WoodRobert JerrisVan Leung-PinedaMark D. GonzalezBeverly B. RogersMaud MavignerRaymond F. SchinaziNils SchoofJesse J. WaggonerRussell R. KempkerPaulina A. RebolledoJared W. O’NealCheryl StoneAnn ChahroudiClaudia R. MorrisAllie SuessmithJulie SullivanSarah FarmerAmanda FosterJohn D. RobackThanuja RamachandraCaDeidre WashingtonKristie LeMaria C. CorderoAnnette EsperEric J. NehlYun F. WangErika A. TyburskiGreg S. MartinWilbur A. LamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Medicine R Science Q |
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Medicine R Science Q Jennifer K. Frediani Joshua M. Levy Anuradha Rao Leda Bassit Janet Figueroa Miriam B. Vos Anna Wood Robert Jerris Van Leung-Pineda Mark D. Gonzalez Beverly B. Rogers Maud Mavigner Raymond F. Schinazi Nils Schoof Jesse J. Waggoner Russell R. Kempker Paulina A. Rebolledo Jared W. O’Neal Cheryl Stone Ann Chahroudi Claudia R. Morris Allie Suessmith Julie Sullivan Sarah Farmer Amanda Foster John D. Roback Thanuja Ramachandra CaDeidre Washington Kristie Le Maria C. Cordero Annette Esper Eric J. Nehl Yun F. Wang Erika A. Tyburski Greg S. Martin Wilbur A. Lam Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration |
| description |
Abstract While there has been significant progress in the development of rapid COVID-19 diagnostics, as the pandemic unfolds, new challenges have emerged, including whether these technologies can reliably detect the more infectious variants of concern and be viably deployed in non-clinical settings as “self-tests”. Multidisciplinary evaluation of the Abbott BinaxNOW COVID-19 Ag Card (BinaxNOW, a widely used rapid antigen test, included limit of detection, variant detection, test performance across different age-groups, and usability with self/caregiver-administration. While BinaxNOW detected the highly infectious variants, B.1.1.7 (Alpha) first identified in the UK, B.1.351 (Beta) first identified in South Africa, P.1 (Gamma) first identified in Brazil, B.1.617.2 (Delta) first identified in India and B.1.2, a non-VOC, test sensitivity decreased with decreasing viral loads. Moreover, BinaxNOW sensitivity trended lower when devices were performed by patients/caregivers themselves compared to trained clinical staff, despite universally high usability assessments following self/caregiver-administration among different age groups. Overall, these data indicate that while BinaxNOW accurately detects the new viral variants, as rapid COVID-19 tests enter the home, their already lower sensitivities compared to RT-PCR may decrease even more due to user error. |
| format |
article |
| author |
Jennifer K. Frediani Joshua M. Levy Anuradha Rao Leda Bassit Janet Figueroa Miriam B. Vos Anna Wood Robert Jerris Van Leung-Pineda Mark D. Gonzalez Beverly B. Rogers Maud Mavigner Raymond F. Schinazi Nils Schoof Jesse J. Waggoner Russell R. Kempker Paulina A. Rebolledo Jared W. O’Neal Cheryl Stone Ann Chahroudi Claudia R. Morris Allie Suessmith Julie Sullivan Sarah Farmer Amanda Foster John D. Roback Thanuja Ramachandra CaDeidre Washington Kristie Le Maria C. Cordero Annette Esper Eric J. Nehl Yun F. Wang Erika A. Tyburski Greg S. Martin Wilbur A. Lam |
| author_facet |
Jennifer K. Frediani Joshua M. Levy Anuradha Rao Leda Bassit Janet Figueroa Miriam B. Vos Anna Wood Robert Jerris Van Leung-Pineda Mark D. Gonzalez Beverly B. Rogers Maud Mavigner Raymond F. Schinazi Nils Schoof Jesse J. Waggoner Russell R. Kempker Paulina A. Rebolledo Jared W. O’Neal Cheryl Stone Ann Chahroudi Claudia R. Morris Allie Suessmith Julie Sullivan Sarah Farmer Amanda Foster John D. Roback Thanuja Ramachandra CaDeidre Washington Kristie Le Maria C. Cordero Annette Esper Eric J. Nehl Yun F. Wang Erika A. Tyburski Greg S. Martin Wilbur A. Lam |
| author_sort |
Jennifer K. Frediani |
| title |
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration |
| title_short |
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration |
| title_full |
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration |
| title_fullStr |
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration |
| title_full_unstemmed |
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration |
| title_sort |
multidisciplinary assessment of the abbott binaxnow sars-cov-2 point-of-care antigen test in the context of emerging viral variants and self-administration |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/30016094be9f470888a58161d2407fd5 |
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