Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4

The Tec family tyrosine kinase, Itk, is a component of the T-cell receptor essential for optimal Th2 responses in vivo. Here the authors show in human cells and mouse models that Itk is also needed for the production of IL-9, an important contributor to allergic asthma.

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Autores principales:	Julio Gomez-Rodriguez, Françoise Meylan, Robin Handon, Erika T. Hayes, Stacie M. Anderson, Martha R. Kirby, Richard M. Siegel, Pamela L. Schwartzberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30020e049b654fe9a3907548fe25c55f
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spelling	oai:doaj.org-article:30020e049b654fe9a3907548fe25c55f2021-12-02T15:34:30ZItk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF410.1038/ncomms108572041-1723https://doaj.org/article/30020e049b654fe9a3907548fe25c55f2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10857https://doaj.org/toc/2041-1723The Tec family tyrosine kinase, Itk, is a component of the T-cell receptor essential for optimal Th2 responses in vivo. Here the authors show in human cells and mouse models that Itk is also needed for the production of IL-9, an important contributor to allergic asthma.Julio Gomez-RodriguezFrançoise MeylanRobin HandonErika T. HayesStacie M. AndersonMartha R. KirbyRichard M. SiegelPamela L. SchwartzbergNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julio Gomez-Rodriguez Françoise Meylan Robin Handon Erika T. Hayes Stacie M. Anderson Martha R. Kirby Richard M. Siegel Pamela L. Schwartzberg Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
description	The Tec family tyrosine kinase, Itk, is a component of the T-cell receptor essential for optimal Th2 responses in vivo. Here the authors show in human cells and mouse models that Itk is also needed for the production of IL-9, an important contributor to allergic asthma.
format	article
author	Julio Gomez-Rodriguez Françoise Meylan Robin Handon Erika T. Hayes Stacie M. Anderson Martha R. Kirby Richard M. Siegel Pamela L. Schwartzberg
author_facet	Julio Gomez-Rodriguez Françoise Meylan Robin Handon Erika T. Hayes Stacie M. Anderson Martha R. Kirby Richard M. Siegel Pamela L. Schwartzberg
author_sort	Julio Gomez-Rodriguez
title	Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
title_short	Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
title_full	Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
title_fullStr	Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
title_full_unstemmed	Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
title_sort	itk is required for th9 differentiation via tcr-mediated induction of il-2 and irf4
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/30020e049b654fe9a3907548fe25c55f
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Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4

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