Two decades (1998 to 2018) of collaborative human immunodeficiency virus clinical pharmacology capacity building in a resource constrained setting

Abstract While important advances have been made in the prevention and treatment of Human Immunodeficiency Virus (HIV) infection, limited expertise and resource constraints to effectively manage rollout of HIV programs often contribute to poor treatment outcomes in Sub-Saharan Africa. In 1998, the U...

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Autores principales:	Charles C. Maponga, Tsitsi G. Monera-Penduka, Takudzwa J. Mtisi, Robin Difrancesco, Faithful Makita-Chingombe, Fine Mazambara, Kathleen Tooley, Tinashe Mudzviti, Gene D. Morse
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	HIV Research Capacity building Clinical pharmacology Collaboration Resource-limited Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/30046bd8124948edb7563cf98f6f2f1d
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spelling	oai:doaj.org-article:30046bd8124948edb7563cf98f6f2f1d2021-11-14T12:30:46ZTwo decades (1998 to 2018) of collaborative human immunodeficiency virus clinical pharmacology capacity building in a resource constrained setting10.1186/s12962-021-00327-y1478-7547https://doaj.org/article/30046bd8124948edb7563cf98f6f2f1d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12962-021-00327-yhttps://doaj.org/toc/1478-7547Abstract While important advances have been made in the prevention and treatment of Human Immunodeficiency Virus (HIV) infection, limited expertise and resource constraints to effectively manage rollout of HIV programs often contribute to poor treatment outcomes in Sub-Saharan Africa. In 1998, the University of Zimbabwe (UZ) and the University at Buffalo, State University of New York (UB), developed a collaborative clinical pharmacology capacity building program in Zimbabwe to train the next generation of HIV researchers and support rollout of the national HIV program. The collaboration was funded by research and training grants that were competitively acquired through United States of America government funding mechanisms, between 1998 and 2016. Thirty-eight research fellows were trained and a specialty clinical pharmacology laboratory was established during this period. Knowledge and skills transfer were achieved through faculty and student exchange visits. Scientific dissemination output included sixty-two scholarly publications that influenced three national policies and provided development of guidelines for strategic leadership for an HIV infection—patient adherence support group. The clinical pharmacology capacity building program trained fellows that were subsequently incorporated into the national technical working group at the Ministry of Health and Child Care, who are responsible for optimizing HIV treatment guidelines in Zimbabwe. Despite serious economic challenges, consistent collaboration between UZ and UB strengthened UZ faculty scholarly capacity, retention of HIV clinical research workforce was achieved, and the program made additional contributions toward optimization of antiretroviral therapy in Zimbabwe.Charles C. MapongaTsitsi G. Monera-PendukaTakudzwa J. MtisiRobin DifrancescoFaithful Makita-ChingombeFine MazambaraKathleen TooleyTinashe MudzvitiGene D. MorseBMCarticleHIVResearchCapacity buildingClinical pharmacologyCollaborationResource-limitedMedicine (General)R5-920ENCost Effectiveness and Resource Allocation, Vol 19, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV Research Capacity building Clinical pharmacology Collaboration Resource-limited Medicine (General) R5-920
spellingShingle	HIV Research Capacity building Clinical pharmacology Collaboration Resource-limited Medicine (General) R5-920 Charles C. Maponga Tsitsi G. Monera-Penduka Takudzwa J. Mtisi Robin Difrancesco Faithful Makita-Chingombe Fine Mazambara Kathleen Tooley Tinashe Mudzviti Gene D. Morse Two decades (1998 to 2018) of collaborative human immunodeficiency virus clinical pharmacology capacity building in a resource constrained setting
description	Abstract While important advances have been made in the prevention and treatment of Human Immunodeficiency Virus (HIV) infection, limited expertise and resource constraints to effectively manage rollout of HIV programs often contribute to poor treatment outcomes in Sub-Saharan Africa. In 1998, the University of Zimbabwe (UZ) and the University at Buffalo, State University of New York (UB), developed a collaborative clinical pharmacology capacity building program in Zimbabwe to train the next generation of HIV researchers and support rollout of the national HIV program. The collaboration was funded by research and training grants that were competitively acquired through United States of America government funding mechanisms, between 1998 and 2016. Thirty-eight research fellows were trained and a specialty clinical pharmacology laboratory was established during this period. Knowledge and skills transfer were achieved through faculty and student exchange visits. Scientific dissemination output included sixty-two scholarly publications that influenced three national policies and provided development of guidelines for strategic leadership for an HIV infection—patient adherence support group. The clinical pharmacology capacity building program trained fellows that were subsequently incorporated into the national technical working group at the Ministry of Health and Child Care, who are responsible for optimizing HIV treatment guidelines in Zimbabwe. Despite serious economic challenges, consistent collaboration between UZ and UB strengthened UZ faculty scholarly capacity, retention of HIV clinical research workforce was achieved, and the program made additional contributions toward optimization of antiretroviral therapy in Zimbabwe.
format	article
author	Charles C. Maponga Tsitsi G. Monera-Penduka Takudzwa J. Mtisi Robin Difrancesco Faithful Makita-Chingombe Fine Mazambara Kathleen Tooley Tinashe Mudzviti Gene D. Morse
author_facet	Charles C. Maponga Tsitsi G. Monera-Penduka Takudzwa J. Mtisi Robin Difrancesco Faithful Makita-Chingombe Fine Mazambara Kathleen Tooley Tinashe Mudzviti Gene D. Morse
author_sort	Charles C. Maponga
title	Two decades (1998 to 2018) of collaborative human immunodeficiency virus clinical pharmacology capacity building in a resource constrained setting
title_short	Two decades (1998 to 2018) of collaborative human immunodeficiency virus clinical pharmacology capacity building in a resource constrained setting
title_full	Two decades (1998 to 2018) of collaborative human immunodeficiency virus clinical pharmacology capacity building in a resource constrained setting
title_fullStr	Two decades (1998 to 2018) of collaborative human immunodeficiency virus clinical pharmacology capacity building in a resource constrained setting
title_full_unstemmed	Two decades (1998 to 2018) of collaborative human immunodeficiency virus clinical pharmacology capacity building in a resource constrained setting
title_sort	two decades (1998 to 2018) of collaborative human immunodeficiency virus clinical pharmacology capacity building in a resource constrained setting
publisher	BMC
publishDate	2021
url	https://doaj.org/article/30046bd8124948edb7563cf98f6f2f1d
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Two decades (1998 to 2018) of collaborative human immunodeficiency virus clinical pharmacology capacity building in a resource constrained setting

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