Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma

Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this interaction inhibits genes involved in neuronal differen...

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Autores principales:	Catherine Lee, Vasilisa A. Rudneva, Serap Erkek, Marc Zapatka, Lianne Q. Chau, Silvia K. Tacheva-Grigorova, Alexandra Garancher, Jessica M. Rusert, Ozlem Aksoy, Robin Lea, Helai P. Mohammad, Jianxun Wang, William A. Weiss, H. Leighton Grimes, Stefan M. Pfister, Paul A. Northcott, Robert J. Wechsler-Reya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3008cdc8884c4e79a131516d3e5463b0
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spelling	oai:doaj.org-article:3008cdc8884c4e79a131516d3e5463b02021-12-02T16:58:18ZLsd1 as a therapeutic target in Gfi1-activated medulloblastoma10.1038/s41467-018-08269-52041-1723https://doaj.org/article/3008cdc8884c4e79a131516d3e5463b02019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08269-5https://doaj.org/toc/2041-1723Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this interaction inhibits genes involved in neuronal differentiation, and that Lsd1 may be a therapeutic target in Gfi1-activated tumors.Catherine LeeVasilisa A. RudnevaSerap ErkekMarc ZapatkaLianne Q. ChauSilvia K. Tacheva-GrigorovaAlexandra GarancherJessica M. RusertOzlem AksoyRobin LeaHelai P. MohammadJianxun WangWilliam A. WeissH. Leighton GrimesStefan M. PfisterPaul A. NorthcottRobert J. Wechsler-ReyaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Catherine Lee Vasilisa A. Rudneva Serap Erkek Marc Zapatka Lianne Q. Chau Silvia K. Tacheva-Grigorova Alexandra Garancher Jessica M. Rusert Ozlem Aksoy Robin Lea Helai P. Mohammad Jianxun Wang William A. Weiss H. Leighton Grimes Stefan M. Pfister Paul A. Northcott Robert J. Wechsler-Reya Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma
description	Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this interaction inhibits genes involved in neuronal differentiation, and that Lsd1 may be a therapeutic target in Gfi1-activated tumors.
format	article
author	Catherine Lee Vasilisa A. Rudneva Serap Erkek Marc Zapatka Lianne Q. Chau Silvia K. Tacheva-Grigorova Alexandra Garancher Jessica M. Rusert Ozlem Aksoy Robin Lea Helai P. Mohammad Jianxun Wang William A. Weiss H. Leighton Grimes Stefan M. Pfister Paul A. Northcott Robert J. Wechsler-Reya
author_facet	Catherine Lee Vasilisa A. Rudneva Serap Erkek Marc Zapatka Lianne Q. Chau Silvia K. Tacheva-Grigorova Alexandra Garancher Jessica M. Rusert Ozlem Aksoy Robin Lea Helai P. Mohammad Jianxun Wang William A. Weiss H. Leighton Grimes Stefan M. Pfister Paul A. Northcott Robert J. Wechsler-Reya
author_sort	Catherine Lee
title	Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma
title_short	Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma
title_full	Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma
title_fullStr	Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma
title_full_unstemmed	Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma
title_sort	lsd1 as a therapeutic target in gfi1-activated medulloblastoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3008cdc8884c4e79a131516d3e5463b0
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Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma

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