Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry

Neuroligins are postsynaptic cell adhesion molecules that are involved in synapse function and autism spectrum disorder. The authors show that NLG2-mediated GABAergic transmission at the thalamic reticular nucleus-thalamic circuit is a common mechanism underlying epileptic seizures and ASD.

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Autores principales:	Feng Cao, Jackie J. Liu, Susan Zhou, Miguel A. Cortez, O. Carter Snead, Jing Han, Zhengping Jia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/300c417812da48fd94b3d818cd2a5150
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spelling	oai:doaj.org-article:300c417812da48fd94b3d818cd2a51502021-12-02T18:47:00ZNeuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry10.1038/s41467-020-17560-32041-1723https://doaj.org/article/300c417812da48fd94b3d818cd2a51502020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17560-3https://doaj.org/toc/2041-1723Neuroligins are postsynaptic cell adhesion molecules that are involved in synapse function and autism spectrum disorder. The authors show that NLG2-mediated GABAergic transmission at the thalamic reticular nucleus-thalamic circuit is a common mechanism underlying epileptic seizures and ASD.Feng CaoJackie J. LiuSusan ZhouMiguel A. CortezO. Carter SneadJing HanZhengping JiaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Feng Cao Jackie J. Liu Susan Zhou Miguel A. Cortez O. Carter Snead Jing Han Zhengping Jia Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry
description	Neuroligins are postsynaptic cell adhesion molecules that are involved in synapse function and autism spectrum disorder. The authors show that NLG2-mediated GABAergic transmission at the thalamic reticular nucleus-thalamic circuit is a common mechanism underlying epileptic seizures and ASD.
format	article
author	Feng Cao Jackie J. Liu Susan Zhou Miguel A. Cortez O. Carter Snead Jing Han Zhengping Jia
author_facet	Feng Cao Jackie J. Liu Susan Zhou Miguel A. Cortez O. Carter Snead Jing Han Zhengping Jia
author_sort	Feng Cao
title	Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry
title_short	Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry
title_full	Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry
title_fullStr	Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry
title_full_unstemmed	Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry
title_sort	neuroligin 2 regulates absence seizures and behavioral arrests through gabaergic transmission within the thalamocortical circuitry
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/300c417812da48fd94b3d818cd2a5150
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Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry

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