NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl-glutathione-coated gold nanoparticles

Abstract Theranostics based on two-photon excitation of therapeutics in the NIR region is an emerging and powerful tool in cancer therapy since this radiation deeply penetrates healthy biological tissues and produces selective cell death. Aggregates of gold nanoparticles coated with glutathione coro...

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Autores principales:	Antonio Buonerba, Rosita Lapenta, Anna Donniacuo, Magda Licasale, Elena Vezzoli, Stefano Milione, Carmine Capacchione, Mario Felice Tecce, Andrea Falqui, Roberto Piacentini, Claudio Grassi, Alfonso Grassi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/300c905aafb8441c8456aaf3c71700cf
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spelling	oai:doaj.org-article:300c905aafb8441c8456aaf3c71700cf2021-12-02T15:39:49ZNIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl-glutathione-coated gold nanoparticles10.1038/s41598-020-68397-12045-2322https://doaj.org/article/300c905aafb8441c8456aaf3c71700cf2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68397-1https://doaj.org/toc/2045-2322Abstract Theranostics based on two-photon excitation of therapeutics in the NIR region is an emerging and powerful tool in cancer therapy since this radiation deeply penetrates healthy biological tissues and produces selective cell death. Aggregates of gold nanoparticles coated with glutathione corona functionalized with the dansyl chromophore (a-DG-AuNPs) were synthesized and found efficient nanodevice for applications in photothermal therapy (PTT). Actually the nanoparticle aggregation enhances the quenching of radiative excitation and the consequent conversion into heat. The a-DG-AuNPs are readily internalized in Hep G2 where the chromophore acts as both antenna and transducer of the NIR radiation under two-photons excitation, determining efficient cell ablation via photothermal effect.Antonio BuonerbaRosita LapentaAnna DonniacuoMagda LicasaleElena VezzoliStefano MilioneCarmine CapacchioneMario Felice TecceAndrea FalquiRoberto PiacentiniClaudio GrassiAlfonso GrassiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antonio Buonerba Rosita Lapenta Anna Donniacuo Magda Licasale Elena Vezzoli Stefano Milione Carmine Capacchione Mario Felice Tecce Andrea Falqui Roberto Piacentini Claudio Grassi Alfonso Grassi NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl-glutathione-coated gold nanoparticles
description	Abstract Theranostics based on two-photon excitation of therapeutics in the NIR region is an emerging and powerful tool in cancer therapy since this radiation deeply penetrates healthy biological tissues and produces selective cell death. Aggregates of gold nanoparticles coated with glutathione corona functionalized with the dansyl chromophore (a-DG-AuNPs) were synthesized and found efficient nanodevice for applications in photothermal therapy (PTT). Actually the nanoparticle aggregation enhances the quenching of radiative excitation and the consequent conversion into heat. The a-DG-AuNPs are readily internalized in Hep G2 where the chromophore acts as both antenna and transducer of the NIR radiation under two-photons excitation, determining efficient cell ablation via photothermal effect.
format	article
author	Antonio Buonerba Rosita Lapenta Anna Donniacuo Magda Licasale Elena Vezzoli Stefano Milione Carmine Capacchione Mario Felice Tecce Andrea Falqui Roberto Piacentini Claudio Grassi Alfonso Grassi
author_facet	Antonio Buonerba Rosita Lapenta Anna Donniacuo Magda Licasale Elena Vezzoli Stefano Milione Carmine Capacchione Mario Felice Tecce Andrea Falqui Roberto Piacentini Claudio Grassi Alfonso Grassi
author_sort	Antonio Buonerba
title	NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl-glutathione-coated gold nanoparticles
title_short	NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl-glutathione-coated gold nanoparticles
title_full	NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl-glutathione-coated gold nanoparticles
title_fullStr	NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl-glutathione-coated gold nanoparticles
title_full_unstemmed	NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl-glutathione-coated gold nanoparticles
title_sort	nir multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl-glutathione-coated gold nanoparticles
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/300c905aafb8441c8456aaf3c71700cf
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NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl-glutathione-coated gold nanoparticles

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