Deletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetes.

Deletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetes.

<h4>Background/objective</h4>The CDKAL1 gene is among the best-replicated susceptibility loci for type 2 diabetes, originally identified by genome-wide association studies in humans. To clarify a physiological importance of CDKAL1, we examined effects of a global Cdkal1-null mutation in...

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Main Authors: Tadashi Okamura, Rieko Yanobu-Takanashi, Fumihiko Takeuchi, Masato Isono, Koichi Akiyama, Yukiko Shimizu, Motohito Goto, Yi-Qiang Liang, Ken Yamamoto, Tomohiro Katsuya, Akihiro Fujioka, Keizo Ohnaka, Ryoichi Takayanagi, Toshio Ogihara, Yukio Yamori, Norihiro Kato
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/300ce441f73e4252bb1dfceb572b9220
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