Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities

Multimorbidities of common diseases often have shared underlying predisposing factors. Here Fadason et al. study the pleiotropy of SNPs and their effects on target genes by integrating chromatin interaction and expression quantitative trait loci data to identify target genes shared between phenotype...

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Autores principales: Tayaza Fadason, William Schierding, Thomas Lumley, Justin M. O’Sullivan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/3010e481d22245b2943cd3ec1cf06e90
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Sumario:Multimorbidities of common diseases often have shared underlying predisposing factors. Here Fadason et al. study the pleiotropy of SNPs and their effects on target genes by integrating chromatin interaction and expression quantitative trait loci data to identify target genes shared between phenotypes.