Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities

Multimorbidities of common diseases often have shared underlying predisposing factors. Here Fadason et al. study the pleiotropy of SNPs and their effects on target genes by integrating chromatin interaction and expression quantitative trait loci data to identify target genes shared between phenotype...

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Autores principales:	Tayaza Fadason, William Schierding, Thomas Lumley, Justin M. O’Sullivan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3010e481d22245b2943cd3ec1cf06e90
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spelling	oai:doaj.org-article:3010e481d22245b2943cd3ec1cf06e902021-12-02T14:40:09ZChromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities10.1038/s41467-018-07692-y2041-1723https://doaj.org/article/3010e481d22245b2943cd3ec1cf06e902018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07692-yhttps://doaj.org/toc/2041-1723Multimorbidities of common diseases often have shared underlying predisposing factors. Here Fadason et al. study the pleiotropy of SNPs and their effects on target genes by integrating chromatin interaction and expression quantitative trait loci data to identify target genes shared between phenotypes.Tayaza FadasonWilliam SchierdingThomas LumleyJustin M. O’SullivanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tayaza Fadason William Schierding Thomas Lumley Justin M. O’Sullivan Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
description	Multimorbidities of common diseases often have shared underlying predisposing factors. Here Fadason et al. study the pleiotropy of SNPs and their effects on target genes by integrating chromatin interaction and expression quantitative trait loci data to identify target genes shared between phenotypes.
format	article
author	Tayaza Fadason William Schierding Thomas Lumley Justin M. O’Sullivan
author_facet	Tayaza Fadason William Schierding Thomas Lumley Justin M. O’Sullivan
author_sort	Tayaza Fadason
title	Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
title_short	Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
title_full	Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
title_fullStr	Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
title_full_unstemmed	Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
title_sort	chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3010e481d22245b2943cd3ec1cf06e90
work_keys_str_mv	AT tayazafadason chromatininteractionsandexpressionquantitativetraitlocirevealgeneticdriversofmultimorbidities AT williamschierding chromatininteractionsandexpressionquantitativetraitlocirevealgeneticdriversofmultimorbidities AT thomaslumley chromatininteractionsandexpressionquantitativetraitlocirevealgeneticdriversofmultimorbidities AT justinmosullivan chromatininteractionsandexpressionquantitativetraitlocirevealgeneticdriversofmultimorbidities
_version_	1718390406371082240

Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities

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