Gut microbiota in Parkinson’s disease patients: hospital-based study

Abstract Background Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. There is accumulating evidence that link gut microbiota to symptomatology and pathophysiology of PD. The aim of this study was to describe the pattern of gut microbiota and its association with PD and...

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Autores principales:	Eman M. Khedr, Anwar M. Ali, Enas Deaf, Hebatallah M. Hassan, Ahmed Alaa, Ayman Gamea
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Gut microbiota Parkinson’s disease GIT domain non‐motor symptoms Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/3015efca1fe3486495ce07b83d474343
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spelling	oai:doaj.org-article:3015efca1fe3486495ce07b83d4743432021-11-08T10:44:31ZGut microbiota in Parkinson’s disease patients: hospital-based study10.1186/s41983-021-00407-z1687-8329https://doaj.org/article/3015efca1fe3486495ce07b83d4743432021-11-01T00:00:00Zhttps://doi.org/10.1186/s41983-021-00407-zhttps://doaj.org/toc/1687-8329Abstract Background Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. There is accumulating evidence that link gut microbiota to symptomatology and pathophysiology of PD. The aim of this study was to describe the pattern of gut microbiota and its association with PD and identify the effect of environmental factors on gut microbiota. This case–control study included 46 patients diagnosed as Parkinson’s disease (PD) and 31 healthy volunteers age and sex matched. Detailed history including age of onset, duration of disease, environmental risk factors, diet data, treatment, Unified Parkinson’s Disease Rating Scale (UPDRS), and gastrointestinal tract (GIT) domain of Non‐Motor Symptoms Scale (NMSS) were assessed. After extraction of bacterial DNA from the fecal samples, bacterial abundance was quantified by qPCR using 16S rRNA group-specific primers. Results Significant high abundance of Clostridium cluster IV, Akkermansia, Bifidobacterium, and lactic acid bacteria were found in the PD group compared with the control group (P < 0.001, 0.04, 0.02 and < 0.001, respectively), while Firmicutes were significantly less abundant in the PD group (P < 0.001) compared with the control group. The naive PD patients had significant abundance of Bifidobacterium, and lactic acid compared with control group. Interestingly, Akkermansia was more abundant in treated than untreated patients. There were significant associations between pesticide exposure and Bifidobacterium (P = 0.002), while no significant correlations between different gut microbiota and demographic, environment data, different rating scores or dominant type of PD. There was a significant negative correlation between the Bifidobacterium with the duration of illness (P = 0.012). Conclusion The present study highlighted a significant connection between PD and levels of certain types of gut microbiota, in support of a possible link between gut microbiota and a neurodegenerative cascade of PD.Eman M. KhedrAnwar M. AliEnas DeafHebatallah M. HassanAhmed AlaaAyman GameaSpringerOpenarticleGut microbiotaParkinson’s diseaseGIT domain non‐motor symptomsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 57, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gut microbiota Parkinson’s disease GIT domain non‐motor symptoms Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Gut microbiota Parkinson’s disease GIT domain non‐motor symptoms Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Eman M. Khedr Anwar M. Ali Enas Deaf Hebatallah M. Hassan Ahmed Alaa Ayman Gamea Gut microbiota in Parkinson’s disease patients: hospital-based study
description	Abstract Background Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. There is accumulating evidence that link gut microbiota to symptomatology and pathophysiology of PD. The aim of this study was to describe the pattern of gut microbiota and its association with PD and identify the effect of environmental factors on gut microbiota. This case–control study included 46 patients diagnosed as Parkinson’s disease (PD) and 31 healthy volunteers age and sex matched. Detailed history including age of onset, duration of disease, environmental risk factors, diet data, treatment, Unified Parkinson’s Disease Rating Scale (UPDRS), and gastrointestinal tract (GIT) domain of Non‐Motor Symptoms Scale (NMSS) were assessed. After extraction of bacterial DNA from the fecal samples, bacterial abundance was quantified by qPCR using 16S rRNA group-specific primers. Results Significant high abundance of Clostridium cluster IV, Akkermansia, Bifidobacterium, and lactic acid bacteria were found in the PD group compared with the control group (P < 0.001, 0.04, 0.02 and < 0.001, respectively), while Firmicutes were significantly less abundant in the PD group (P < 0.001) compared with the control group. The naive PD patients had significant abundance of Bifidobacterium, and lactic acid compared with control group. Interestingly, Akkermansia was more abundant in treated than untreated patients. There were significant associations between pesticide exposure and Bifidobacterium (P = 0.002), while no significant correlations between different gut microbiota and demographic, environment data, different rating scores or dominant type of PD. There was a significant negative correlation between the Bifidobacterium with the duration of illness (P = 0.012). Conclusion The present study highlighted a significant connection between PD and levels of certain types of gut microbiota, in support of a possible link between gut microbiota and a neurodegenerative cascade of PD.
format	article
author	Eman M. Khedr Anwar M. Ali Enas Deaf Hebatallah M. Hassan Ahmed Alaa Ayman Gamea
author_facet	Eman M. Khedr Anwar M. Ali Enas Deaf Hebatallah M. Hassan Ahmed Alaa Ayman Gamea
author_sort	Eman M. Khedr
title	Gut microbiota in Parkinson’s disease patients: hospital-based study
title_short	Gut microbiota in Parkinson’s disease patients: hospital-based study
title_full	Gut microbiota in Parkinson’s disease patients: hospital-based study
title_fullStr	Gut microbiota in Parkinson’s disease patients: hospital-based study
title_full_unstemmed	Gut microbiota in Parkinson’s disease patients: hospital-based study
title_sort	gut microbiota in parkinson’s disease patients: hospital-based study
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/3015efca1fe3486495ce07b83d474343
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Gut microbiota in Parkinson’s disease patients: hospital-based study

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