Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency

Abstract The relationship between vitamin D deficiency and the risk of suffering from a plethora of health disorders, ranging from autoimmune processes to infectious diseases has been widely described. Nonetheless, the potential role of vitamin D in visceral leishmaniasis remains uncharacterized. In...

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Autores principales:	A. Rodriguez-Cortes, C. Martori, A. Martinez-Florez, A. Clop, M. Amills, J. Kubejko, J. Llull, J. M. Nadal, J. Alberola
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30167d972ff34932adc6725994fb408b
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spelling	oai:doaj.org-article:30167d972ff34932adc6725994fb408b2021-12-02T16:07:01ZCanine Leishmaniasis Progression is Associated with Vitamin D Deficiency10.1038/s41598-017-03662-42045-2322https://doaj.org/article/30167d972ff34932adc6725994fb408b2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03662-4https://doaj.org/toc/2045-2322Abstract The relationship between vitamin D deficiency and the risk of suffering from a plethora of health disorders, ranging from autoimmune processes to infectious diseases has been widely described. Nonetheless, the potential role of vitamin D in visceral leishmaniasis remains uncharacterized. In the Mediterranean basin, where the dog is leishmania’s main peri-domestic reservoir, control measures against the canine disease have shown beneficial effects on the incidence of human leishmaniasis. In this study, we measured the vitamin D levels in serum samples from a cohort of 68 healthy and disease dogs from a highly endemic area and we have also studied the relationship of these levels with parasitological and immunological parameters. The sick dogs presented significantly lower (P < 0.001) vitamin D levels (19.6 ng/mL) than their non-infected (31.8 ng/mL) and the asymptomatic counterparts (29.6 ng/mL). In addition, vitamin D deficiency correlated with several parameters linked to leishmaniasis progression. However, there was no correlation between vitamin D levels and the Leishmania-specific cellular immune response. Moreover, both the leishmanin skin test and the IFN-γ levels displayed negative correlations with serological, parasitological and clinical signs. Further studies to determine the functional role of vitamin D on the progression and control of canine leishmaniasis are needed.A. Rodriguez-CortesC. MartoriA. Martinez-FlorezA. ClopM. AmillsJ. KubejkoJ. LlullJ. M. NadalJ. AlberolaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. Rodriguez-Cortes C. Martori A. Martinez-Florez A. Clop M. Amills J. Kubejko J. Llull J. M. Nadal J. Alberola Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency
description	Abstract The relationship between vitamin D deficiency and the risk of suffering from a plethora of health disorders, ranging from autoimmune processes to infectious diseases has been widely described. Nonetheless, the potential role of vitamin D in visceral leishmaniasis remains uncharacterized. In the Mediterranean basin, where the dog is leishmania’s main peri-domestic reservoir, control measures against the canine disease have shown beneficial effects on the incidence of human leishmaniasis. In this study, we measured the vitamin D levels in serum samples from a cohort of 68 healthy and disease dogs from a highly endemic area and we have also studied the relationship of these levels with parasitological and immunological parameters. The sick dogs presented significantly lower (P < 0.001) vitamin D levels (19.6 ng/mL) than their non-infected (31.8 ng/mL) and the asymptomatic counterparts (29.6 ng/mL). In addition, vitamin D deficiency correlated with several parameters linked to leishmaniasis progression. However, there was no correlation between vitamin D levels and the Leishmania-specific cellular immune response. Moreover, both the leishmanin skin test and the IFN-γ levels displayed negative correlations with serological, parasitological and clinical signs. Further studies to determine the functional role of vitamin D on the progression and control of canine leishmaniasis are needed.
format	article
author	A. Rodriguez-Cortes C. Martori A. Martinez-Florez A. Clop M. Amills J. Kubejko J. Llull J. M. Nadal J. Alberola
author_facet	A. Rodriguez-Cortes C. Martori A. Martinez-Florez A. Clop M. Amills J. Kubejko J. Llull J. M. Nadal J. Alberola
author_sort	A. Rodriguez-Cortes
title	Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency
title_short	Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency
title_full	Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency
title_fullStr	Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency
title_full_unstemmed	Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency
title_sort	canine leishmaniasis progression is associated with vitamin d deficiency
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/30167d972ff34932adc6725994fb408b
work_keys_str_mv	AT arodriguezcortes canineleishmaniasisprogressionisassociatedwithvitaminddeficiency AT cmartori canineleishmaniasisprogressionisassociatedwithvitaminddeficiency AT amartinezflorez canineleishmaniasisprogressionisassociatedwithvitaminddeficiency AT aclop canineleishmaniasisprogressionisassociatedwithvitaminddeficiency AT mamills canineleishmaniasisprogressionisassociatedwithvitaminddeficiency AT jkubejko canineleishmaniasisprogressionisassociatedwithvitaminddeficiency AT jllull canineleishmaniasisprogressionisassociatedwithvitaminddeficiency AT jmnadal canineleishmaniasisprogressionisassociatedwithvitaminddeficiency AT jalberola canineleishmaniasisprogressionisassociatedwithvitaminddeficiency
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Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency

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