Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma

Glucocorticoids (GC) are commonly used to suppress undesirable inflammatory responses. Here the authors show, using hi-dimensional flow cytometry data, that GC treatment following major surgeries alters adaptive immunity without significant modulation of innate immune responses or pain/functional im...

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Autores principales:	Edward A. Ganio, Natalie Stanley, Viktoria Lindberg-Larsen, Jakob Einhaus, Amy S. Tsai, Franck Verdonk, Anthony Culos, Sajjad Ghaemi, Kristen K. Rumer, Ina A. Stelzer, Dyani Gaudilliere, Eileen Tsai, Ramin Fallahzadeh, Benjamin Choisy, Henrik Kehlet, Nima Aghaeepour, Martin S. Angst, Brice Gaudilliere
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3016b93a2903454094208dd5c4152489
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spelling	oai:doaj.org-article:3016b93a2903454094208dd5c41524892021-12-02T18:47:02ZPreferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma10.1038/s41467-020-17565-y2041-1723https://doaj.org/article/3016b93a2903454094208dd5c41524892020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17565-yhttps://doaj.org/toc/2041-1723Glucocorticoids (GC) are commonly used to suppress undesirable inflammatory responses. Here the authors show, using hi-dimensional flow cytometry data, that GC treatment following major surgeries alters adaptive immunity without significant modulation of innate immune responses or pain/functional impairment.Edward A. GanioNatalie StanleyViktoria Lindberg-LarsenJakob EinhausAmy S. TsaiFranck VerdonkAnthony CulosSajjad GhaemiKristen K. RumerIna A. StelzerDyani GaudilliereEileen TsaiRamin FallahzadehBenjamin ChoisyHenrik KehletNima AghaeepourMartin S. AngstBrice GaudilliereNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Edward A. Ganio Natalie Stanley Viktoria Lindberg-Larsen Jakob Einhaus Amy S. Tsai Franck Verdonk Anthony Culos Sajjad Ghaemi Kristen K. Rumer Ina A. Stelzer Dyani Gaudilliere Eileen Tsai Ramin Fallahzadeh Benjamin Choisy Henrik Kehlet Nima Aghaeepour Martin S. Angst Brice Gaudilliere Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma
description	Glucocorticoids (GC) are commonly used to suppress undesirable inflammatory responses. Here the authors show, using hi-dimensional flow cytometry data, that GC treatment following major surgeries alters adaptive immunity without significant modulation of innate immune responses or pain/functional impairment.
format	article
author	Edward A. Ganio Natalie Stanley Viktoria Lindberg-Larsen Jakob Einhaus Amy S. Tsai Franck Verdonk Anthony Culos Sajjad Ghaemi Kristen K. Rumer Ina A. Stelzer Dyani Gaudilliere Eileen Tsai Ramin Fallahzadeh Benjamin Choisy Henrik Kehlet Nima Aghaeepour Martin S. Angst Brice Gaudilliere
author_facet	Edward A. Ganio Natalie Stanley Viktoria Lindberg-Larsen Jakob Einhaus Amy S. Tsai Franck Verdonk Anthony Culos Sajjad Ghaemi Kristen K. Rumer Ina A. Stelzer Dyani Gaudilliere Eileen Tsai Ramin Fallahzadeh Benjamin Choisy Henrik Kehlet Nima Aghaeepour Martin S. Angst Brice Gaudilliere
author_sort	Edward A. Ganio
title	Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma
title_short	Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma
title_full	Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma
title_fullStr	Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma
title_full_unstemmed	Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma
title_sort	preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3016b93a2903454094208dd5c4152489
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Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma

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