FEATURES OF IMMUNE RESPONSE AMONG MAJOR LYMPHOCYTE SUBPOPULATIONS FROM PERIPHERAL BLOOD DURING EXACERBATION OF CHRONIC GASTRITIS

The aim of this study was to identify and evaluate the features of immune response for main subpopulations of peripheral blood lymphocytes during exacerbation of chronic gastritis, depending on the severity of gastric mucosal atrophy. A comprehensive survey of 122 patients with acute exacerbation of...

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Autor principal:	L. V. Matveeva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	lymphocyte subpopulations interleukins interferon chronic gastritis gastric mucosa atrophy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/3018ee6bc69a4802b52629cae6bd0aed
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spelling	oai:doaj.org-article:3018ee6bc69a4802b52629cae6bd0aed2021-11-18T08:03:44ZFEATURES OF IMMUNE RESPONSE AMONG MAJOR LYMPHOCYTE SUBPOPULATIONS FROM PERIPHERAL BLOOD DURING EXACERBATION OF CHRONIC GASTRITIS1563-06252313-741X10.15789/1563-0625-2015-1-27-32https://doaj.org/article/3018ee6bc69a4802b52629cae6bd0aed2015-03-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/804https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe aim of this study was to identify and evaluate the features of immune response for main subpopulations of peripheral blood lymphocytes during exacerbation of chronic gastritis, depending on the severity of gastric mucosal atrophy. A comprehensive survey of 122 patients with acute exacerbation of chronic gastritis was performed. The patients with chronic focal-atrophic and atrophic gastritis in acute stage were characterized by increased numbers of CD3+ lymphocytes, CD4+, CD8+ and CD16+ cell populations, decreased CD19+ lymphocyte counts in peripheral blood. During exacerbation of non-atrophic gastritis, an increase of CD4+ and CD16+ cell counts was associated with a decrease in the CD8+ and CD19+ lymphocytes. A concomitant increase in CD4+ cell numbers, as well as elevated IL-2 and IFNγ levels in peripheral blood of patients may reflect activation of cellular immunity, which could be induced by the dysplasia of gastric mucosa and co-infection with Helicobacter/herpesvirus. Domination of increased IL-2 and IFNγ over IL-4 and IL-10 levels suggests the Th1-profile of cellular immune response. Upon exacerbation of non-atrophic gastritis, the immunoregulatory index exceeded the values of clinically healthy subjects and those of patients with atrophic gastritis. We observed statistically significant differences for CD3+, CD4+, CD8+, CD19+ lymphocytes, immunoregulatory index, and serum levels of IL-2, depending on presence and severity of gastric mucosal atrophy.L. V. MatveevaSPb RAACIarticlelymphocyte subpopulationsinterleukinsinterferonchronic gastritisgastric mucosa atrophyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 1, Pp 27-32 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	lymphocyte subpopulations interleukins interferon chronic gastritis gastric mucosa atrophy Immunologic diseases. Allergy RC581-607
spellingShingle	lymphocyte subpopulations interleukins interferon chronic gastritis gastric mucosa atrophy Immunologic diseases. Allergy RC581-607 L. V. Matveeva FEATURES OF IMMUNE RESPONSE AMONG MAJOR LYMPHOCYTE SUBPOPULATIONS FROM PERIPHERAL BLOOD DURING EXACERBATION OF CHRONIC GASTRITIS
description	The aim of this study was to identify and evaluate the features of immune response for main subpopulations of peripheral blood lymphocytes during exacerbation of chronic gastritis, depending on the severity of gastric mucosal atrophy. A comprehensive survey of 122 patients with acute exacerbation of chronic gastritis was performed. The patients with chronic focal-atrophic and atrophic gastritis in acute stage were characterized by increased numbers of CD3+ lymphocytes, CD4+, CD8+ and CD16+ cell populations, decreased CD19+ lymphocyte counts in peripheral blood. During exacerbation of non-atrophic gastritis, an increase of CD4+ and CD16+ cell counts was associated with a decrease in the CD8+ and CD19+ lymphocytes. A concomitant increase in CD4+ cell numbers, as well as elevated IL-2 and IFNγ levels in peripheral blood of patients may reflect activation of cellular immunity, which could be induced by the dysplasia of gastric mucosa and co-infection with Helicobacter/herpesvirus. Domination of increased IL-2 and IFNγ over IL-4 and IL-10 levels suggests the Th1-profile of cellular immune response. Upon exacerbation of non-atrophic gastritis, the immunoregulatory index exceeded the values of clinically healthy subjects and those of patients with atrophic gastritis. We observed statistically significant differences for CD3+, CD4+, CD8+, CD19+ lymphocytes, immunoregulatory index, and serum levels of IL-2, depending on presence and severity of gastric mucosal atrophy.
format	article
author	L. V. Matveeva
author_facet	L. V. Matveeva
author_sort	L. V. Matveeva
title	FEATURES OF IMMUNE RESPONSE AMONG MAJOR LYMPHOCYTE SUBPOPULATIONS FROM PERIPHERAL BLOOD DURING EXACERBATION OF CHRONIC GASTRITIS
title_short	FEATURES OF IMMUNE RESPONSE AMONG MAJOR LYMPHOCYTE SUBPOPULATIONS FROM PERIPHERAL BLOOD DURING EXACERBATION OF CHRONIC GASTRITIS
title_full	FEATURES OF IMMUNE RESPONSE AMONG MAJOR LYMPHOCYTE SUBPOPULATIONS FROM PERIPHERAL BLOOD DURING EXACERBATION OF CHRONIC GASTRITIS
title_fullStr	FEATURES OF IMMUNE RESPONSE AMONG MAJOR LYMPHOCYTE SUBPOPULATIONS FROM PERIPHERAL BLOOD DURING EXACERBATION OF CHRONIC GASTRITIS
title_full_unstemmed	FEATURES OF IMMUNE RESPONSE AMONG MAJOR LYMPHOCYTE SUBPOPULATIONS FROM PERIPHERAL BLOOD DURING EXACERBATION OF CHRONIC GASTRITIS
title_sort	features of immune response among major lymphocyte subpopulations from peripheral blood during exacerbation of chronic gastritis
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/3018ee6bc69a4802b52629cae6bd0aed
work_keys_str_mv	AT lvmatveeva featuresofimmuneresponseamongmajorlymphocytesubpopulationsfromperipheralbloodduringexacerbationofchronicgastritis
_version_	1718422407212957696

FEATURES OF IMMUNE RESPONSE AMONG MAJOR LYMPHOCYTE SUBPOPULATIONS FROM PERIPHERAL BLOOD DURING EXACERBATION OF CHRONIC GASTRITIS

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