Temporal Trends in Diagnosis, Treatments, and Outcomes in Patients With Bicuspid Aortic Valve

Background: The population is aging and advances in multimodal imaging and transcatheter valve intervention have been prominent in the past two decades. This study investigated temporal trends in demographic characteristics, use of multimodal imaging, treatments, and outcomes in patients with bicusp...

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Autores principales:	Kyu Kim, Dae-Young Kim, Jiwon Seo, Iksung Cho, Geu-Ru Hong, Jong-Won Ha, Chi Young Shim
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bicuspid aortic valve trend diagnosis imaging treatment outcome Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/301aa38d841e4e80b4af976b84de26c7
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spelling	oai:doaj.org-article:301aa38d841e4e80b4af976b84de26c72021-11-04T06:33:54ZTemporal Trends in Diagnosis, Treatments, and Outcomes in Patients With Bicuspid Aortic Valve2297-055X10.3389/fcvm.2021.766430https://doaj.org/article/301aa38d841e4e80b4af976b84de26c72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.766430/fullhttps://doaj.org/toc/2297-055XBackground: The population is aging and advances in multimodal imaging and transcatheter valve intervention have been prominent in the past two decades. This study investigated temporal trends in demographic characteristics, use of multimodal imaging, treatments, and outcomes in patients with bicuspid aortic valve (BAV).Methods and Results: A total of 1,497 patients (male 71.7%, 57 ± 14 years old) first diagnosed with BAV between January 2003 and December 2020, in a single tertiary center were divided into three groups according to year of diagnosis: group 1 (2003–2008, n = 269), group 2 (2009–2014, n = 594), and group 3 (2015–2020, n = 634). The patients' demographic characteristics, comorbidities, BAV morphology, BAV function, BAV-related disease, use of multimodal diagnostic imaging, treatment modality for BAV, and clinical outcomes were compared among the three groups. The ages at diagnosis and at the time of surgery/intervention increased considerably from group 1 to 3. The patients' comorbidity index also increased progressively. The proportion of non-dysfunctional BAV and significant AS increased, while that of significant AR decreased. The frequency of infective endocarditis as an initial presentation significantly decreased over time. Additionally, the use of multimodal imaging increased markedly in the most recent group. The results also indicated increasing trends in the use of bioprosthetic valves and transcatheter aortic valve replacement. Overall and cardiovascular survival rates improved from group 1 to 3 (log rank p < 0.001).Conclusions: For the past two decades, remarkable temporal changes have occurred in patient characteristics, use of multimodal diagnostic imaging, choice of treatment modality, and clinical outcomes in patients with BAV.Kyu KimDae-Young KimJiwon SeoIksung ChoGeu-Ru HongJong-Won HaChi Young ShimFrontiers Media S.A.articlebicuspid aortic valvetrenddiagnosisimagingtreatmentoutcomeDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bicuspid aortic valve trend diagnosis imaging treatment outcome Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	bicuspid aortic valve trend diagnosis imaging treatment outcome Diseases of the circulatory (Cardiovascular) system RC666-701 Kyu Kim Dae-Young Kim Jiwon Seo Iksung Cho Geu-Ru Hong Jong-Won Ha Chi Young Shim Temporal Trends in Diagnosis, Treatments, and Outcomes in Patients With Bicuspid Aortic Valve
description	Background: The population is aging and advances in multimodal imaging and transcatheter valve intervention have been prominent in the past two decades. This study investigated temporal trends in demographic characteristics, use of multimodal imaging, treatments, and outcomes in patients with bicuspid aortic valve (BAV).Methods and Results: A total of 1,497 patients (male 71.7%, 57 ± 14 years old) first diagnosed with BAV between January 2003 and December 2020, in a single tertiary center were divided into three groups according to year of diagnosis: group 1 (2003–2008, n = 269), group 2 (2009–2014, n = 594), and group 3 (2015–2020, n = 634). The patients' demographic characteristics, comorbidities, BAV morphology, BAV function, BAV-related disease, use of multimodal diagnostic imaging, treatment modality for BAV, and clinical outcomes were compared among the three groups. The ages at diagnosis and at the time of surgery/intervention increased considerably from group 1 to 3. The patients' comorbidity index also increased progressively. The proportion of non-dysfunctional BAV and significant AS increased, while that of significant AR decreased. The frequency of infective endocarditis as an initial presentation significantly decreased over time. Additionally, the use of multimodal imaging increased markedly in the most recent group. The results also indicated increasing trends in the use of bioprosthetic valves and transcatheter aortic valve replacement. Overall and cardiovascular survival rates improved from group 1 to 3 (log rank p < 0.001).Conclusions: For the past two decades, remarkable temporal changes have occurred in patient characteristics, use of multimodal diagnostic imaging, choice of treatment modality, and clinical outcomes in patients with BAV.
format	article
author	Kyu Kim Dae-Young Kim Jiwon Seo Iksung Cho Geu-Ru Hong Jong-Won Ha Chi Young Shim
author_facet	Kyu Kim Dae-Young Kim Jiwon Seo Iksung Cho Geu-Ru Hong Jong-Won Ha Chi Young Shim
author_sort	Kyu Kim
title	Temporal Trends in Diagnosis, Treatments, and Outcomes in Patients With Bicuspid Aortic Valve
title_short	Temporal Trends in Diagnosis, Treatments, and Outcomes in Patients With Bicuspid Aortic Valve
title_full	Temporal Trends in Diagnosis, Treatments, and Outcomes in Patients With Bicuspid Aortic Valve
title_fullStr	Temporal Trends in Diagnosis, Treatments, and Outcomes in Patients With Bicuspid Aortic Valve
title_full_unstemmed	Temporal Trends in Diagnosis, Treatments, and Outcomes in Patients With Bicuspid Aortic Valve
title_sort	temporal trends in diagnosis, treatments, and outcomes in patients with bicuspid aortic valve
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/301aa38d841e4e80b4af976b84de26c7
work_keys_str_mv	AT kyukim temporaltrendsindiagnosistreatmentsandoutcomesinpatientswithbicuspidaorticvalve AT daeyoungkim temporaltrendsindiagnosistreatmentsandoutcomesinpatientswithbicuspidaorticvalve AT jiwonseo temporaltrendsindiagnosistreatmentsandoutcomesinpatientswithbicuspidaorticvalve AT iksungcho temporaltrendsindiagnosistreatmentsandoutcomesinpatientswithbicuspidaorticvalve AT geuruhong temporaltrendsindiagnosistreatmentsandoutcomesinpatientswithbicuspidaorticvalve AT jongwonha temporaltrendsindiagnosistreatmentsandoutcomesinpatientswithbicuspidaorticvalve AT chiyoungshim temporaltrendsindiagnosistreatmentsandoutcomesinpatientswithbicuspidaorticvalve
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Temporal Trends in Diagnosis, Treatments, and Outcomes in Patients With Bicuspid Aortic Valve

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