Genetic characteristics and pathogenesis of H5 low pathogenic avian influenza viruses from wild birds and domestic ducks in South Korea

Abstract H5 and H7 subtypes of low pathogenic avian influenza viruses (LPAIVs) can mutate to highly pathogenic forms and are therefore subject to stringent controls. We characterized H5 LPAIVs isolated from wild-bird habitats and duck farms in South Korea from 2010 to 2017. Through nationwide active...

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Autores principales:	Yu-Na Lee, Dong-Hun Lee, Sun-Ha Cheon, Yu-Ri Park, Yoon-Gi Baek, Young-Jae Si, Soo-Jeong Kye, Eun-Kyoung Lee, Gyeong-Beom Heo, You-Chan Bae, Myoung-Heon Lee, Youn-Jeong Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/301b6ed4367b4920981257f159115e35
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spelling	oai:doaj.org-article:301b6ed4367b4920981257f159115e352021-12-02T16:26:22ZGenetic characteristics and pathogenesis of H5 low pathogenic avian influenza viruses from wild birds and domestic ducks in South Korea10.1038/s41598-020-68720-w2045-2322https://doaj.org/article/301b6ed4367b4920981257f159115e352020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68720-whttps://doaj.org/toc/2045-2322Abstract H5 and H7 subtypes of low pathogenic avian influenza viruses (LPAIVs) can mutate to highly pathogenic forms and are therefore subject to stringent controls. We characterized H5 LPAIVs isolated from wild-bird habitats and duck farms in South Korea from 2010 to 2017. Through nationwide active surveillance for AIVs, 59 H5 LPAIVs were isolated from wild-bird habitats (a mean annual rate of 5.3% of AIV isolations). In 2015, one LPAI H5N3 strain was isolated on a duck farm. Phylogenetic analysis revealed that the hemagglutinin (HA) gene of H5 isolates belonged to the Eurasian lineage, classified into three subgroups (HA-II, HA-III, and HA-IV). The H5 LPAIVs of the HA-III and HA-IV subgroups appeared in 2015 and 2017 in unusually high proportions (13.1% and 14.4%, respectively). In gene-constellation analysis, H5 LPAIVs isolated from 2015 to 2017 constituted ≥ 35 distinct genotypes, representing high levels of genetic diversity. Representative strains of three HA subgroups replicated restrictively in specific-pathogen-free chickens. Among the 11 isolates that were tested, 10 infected and replicated in mice without prior adaptation. The frequency of recent H5 LPAIV isolates with high genetic diversity indicates the importance of continued surveillance in both wild birds and poultry to monitor genetic and pathobiological changes.Yu-Na LeeDong-Hun LeeSun-Ha CheonYu-Ri ParkYoon-Gi BaekYoung-Jae SiSoo-Jeong KyeEun-Kyoung LeeGyeong-Beom HeoYou-Chan BaeMyoung-Heon LeeYoun-Jeong LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Na Lee Dong-Hun Lee Sun-Ha Cheon Yu-Ri Park Yoon-Gi Baek Young-Jae Si Soo-Jeong Kye Eun-Kyoung Lee Gyeong-Beom Heo You-Chan Bae Myoung-Heon Lee Youn-Jeong Lee Genetic characteristics and pathogenesis of H5 low pathogenic avian influenza viruses from wild birds and domestic ducks in South Korea
description	Abstract H5 and H7 subtypes of low pathogenic avian influenza viruses (LPAIVs) can mutate to highly pathogenic forms and are therefore subject to stringent controls. We characterized H5 LPAIVs isolated from wild-bird habitats and duck farms in South Korea from 2010 to 2017. Through nationwide active surveillance for AIVs, 59 H5 LPAIVs were isolated from wild-bird habitats (a mean annual rate of 5.3% of AIV isolations). In 2015, one LPAI H5N3 strain was isolated on a duck farm. Phylogenetic analysis revealed that the hemagglutinin (HA) gene of H5 isolates belonged to the Eurasian lineage, classified into three subgroups (HA-II, HA-III, and HA-IV). The H5 LPAIVs of the HA-III and HA-IV subgroups appeared in 2015 and 2017 in unusually high proportions (13.1% and 14.4%, respectively). In gene-constellation analysis, H5 LPAIVs isolated from 2015 to 2017 constituted ≥ 35 distinct genotypes, representing high levels of genetic diversity. Representative strains of three HA subgroups replicated restrictively in specific-pathogen-free chickens. Among the 11 isolates that were tested, 10 infected and replicated in mice without prior adaptation. The frequency of recent H5 LPAIV isolates with high genetic diversity indicates the importance of continued surveillance in both wild birds and poultry to monitor genetic and pathobiological changes.
format	article
author	Yu-Na Lee Dong-Hun Lee Sun-Ha Cheon Yu-Ri Park Yoon-Gi Baek Young-Jae Si Soo-Jeong Kye Eun-Kyoung Lee Gyeong-Beom Heo You-Chan Bae Myoung-Heon Lee Youn-Jeong Lee
author_facet	Yu-Na Lee Dong-Hun Lee Sun-Ha Cheon Yu-Ri Park Yoon-Gi Baek Young-Jae Si Soo-Jeong Kye Eun-Kyoung Lee Gyeong-Beom Heo You-Chan Bae Myoung-Heon Lee Youn-Jeong Lee
author_sort	Yu-Na Lee
title	Genetic characteristics and pathogenesis of H5 low pathogenic avian influenza viruses from wild birds and domestic ducks in South Korea
title_short	Genetic characteristics and pathogenesis of H5 low pathogenic avian influenza viruses from wild birds and domestic ducks in South Korea
title_full	Genetic characteristics and pathogenesis of H5 low pathogenic avian influenza viruses from wild birds and domestic ducks in South Korea
title_fullStr	Genetic characteristics and pathogenesis of H5 low pathogenic avian influenza viruses from wild birds and domestic ducks in South Korea
title_full_unstemmed	Genetic characteristics and pathogenesis of H5 low pathogenic avian influenza viruses from wild birds and domestic ducks in South Korea
title_sort	genetic characteristics and pathogenesis of h5 low pathogenic avian influenza viruses from wild birds and domestic ducks in south korea
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/301b6ed4367b4920981257f159115e35
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Genetic characteristics and pathogenesis of H5 low pathogenic avian influenza viruses from wild birds and domestic ducks in South Korea

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