Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications

Abstract This paper presents the first demonstration of deeply penetrating dose delivery using focused very high energy electron (VHEE) beams using quadrupole magnets in Monte Carlo simulations. We show that the focal point is readily modified by linearly changing the quadrupole magnet strength only...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	L. Whitmore, R. I. Mackay, M. van Herk, J. K. Jones, R. M. Jones
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/301d72ac93e941d5868761aeed005db8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:301d72ac93e941d5868761aeed005db8
record_format	dspace
spelling	oai:doaj.org-article:301d72ac93e941d5868761aeed005db82021-12-02T15:39:59ZFocused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications10.1038/s41598-021-93276-82045-2322https://doaj.org/article/301d72ac93e941d5868761aeed005db82021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93276-8https://doaj.org/toc/2045-2322Abstract This paper presents the first demonstration of deeply penetrating dose delivery using focused very high energy electron (VHEE) beams using quadrupole magnets in Monte Carlo simulations. We show that the focal point is readily modified by linearly changing the quadrupole magnet strength only. We also present a weighted sum of focused electron beams to form a spread-out electron peak (SOEP) over a target region. This has a significantly reduced entrance dose compared to a proton-based spread-out Bragg peak (SOBP). Very high energy electron (VHEE) beams are an exciting prospect in external beam radiotherapy. VHEEs are less sensitive to inhomogeneities than proton and photon beams, have a deep dose reach and could potentially be used to deliver FLASH radiotherapy. The dose distributions of unfocused VHEE produce high entrance and exit doses compared to other radiotherapy modalities unless focusing is employed, and in this case the entrance dose is considerably improved over existing radiations. We have investigated both symmetric and asymmetric focusing as well as focusing with a range of beam energies.L. WhitmoreR. I. MackayM. van HerkJ. K. JonesR. M. JonesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q L. Whitmore R. I. Mackay M. van Herk J. K. Jones R. M. Jones Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications
description	Abstract This paper presents the first demonstration of deeply penetrating dose delivery using focused very high energy electron (VHEE) beams using quadrupole magnets in Monte Carlo simulations. We show that the focal point is readily modified by linearly changing the quadrupole magnet strength only. We also present a weighted sum of focused electron beams to form a spread-out electron peak (SOEP) over a target region. This has a significantly reduced entrance dose compared to a proton-based spread-out Bragg peak (SOBP). Very high energy electron (VHEE) beams are an exciting prospect in external beam radiotherapy. VHEEs are less sensitive to inhomogeneities than proton and photon beams, have a deep dose reach and could potentially be used to deliver FLASH radiotherapy. The dose distributions of unfocused VHEE produce high entrance and exit doses compared to other radiotherapy modalities unless focusing is employed, and in this case the entrance dose is considerably improved over existing radiations. We have investigated both symmetric and asymmetric focusing as well as focusing with a range of beam energies.
format	article
author	L. Whitmore R. I. Mackay M. van Herk J. K. Jones R. M. Jones
author_facet	L. Whitmore R. I. Mackay M. van Herk J. K. Jones R. M. Jones
author_sort	L. Whitmore
title	Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications
title_short	Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications
title_full	Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications
title_fullStr	Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications
title_full_unstemmed	Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications
title_sort	focused vhee (very high energy electron) beams and dose delivery for radiotherapy applications
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/301d72ac93e941d5868761aeed005db8
work_keys_str_mv	AT lwhitmore focusedvheeveryhighenergyelectronbeamsanddosedeliveryforradiotherapyapplications AT rimackay focusedvheeveryhighenergyelectronbeamsanddosedeliveryforradiotherapyapplications AT mvanherk focusedvheeveryhighenergyelectronbeamsanddosedeliveryforradiotherapyapplications AT jkjones focusedvheeveryhighenergyelectronbeamsanddosedeliveryforradiotherapyapplications AT rmjones focusedvheeveryhighenergyelectronbeamsanddosedeliveryforradiotherapyapplications
_version_	1718385863466942464

Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications

Ejemplares similares