Mesenchymal stromal cell apoptosis is required for their therapeutic function

Mesenchymal stromal cells (MSCs) demonstrate therapeutic benefits in multiple diseases, but the mechanisms remain unclear as infused MSCs do not persist in the body. Here, the authors show that MSC apoptosis is an important mechanistic element, as MSCs rendered genetically incapable of apoptosis los...

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Autores principales:	Swee Heng Milon Pang, Joshua D’Rozario, Senora Mendonca, Tejasvini Bhuvan, Natalie L. Payne, Di Zheng, Assifa Hisana, Georgia Wallis, Adele Barugahare, David Powell, Jai Rautela, Nicholas D. Huntington, Grant Dewson, David C. S. Huang, Daniel H. D. Gray, Tracy S. P. Heng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/301d7cf4f8394cb5843dbd85fe61a7dd
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spelling	oai:doaj.org-article:301d7cf4f8394cb5843dbd85fe61a7dd2021-11-14T12:36:10ZMesenchymal stromal cell apoptosis is required for their therapeutic function10.1038/s41467-021-26834-32041-1723https://doaj.org/article/301d7cf4f8394cb5843dbd85fe61a7dd2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26834-3https://doaj.org/toc/2041-1723Mesenchymal stromal cells (MSCs) demonstrate therapeutic benefits in multiple diseases, but the mechanisms remain unclear as infused MSCs do not persist in the body. Here, the authors show that MSC apoptosis is an important mechanistic element, as MSCs rendered genetically incapable of apoptosis lose their ability to ameliorate disease.Swee Heng Milon PangJoshua D’RozarioSenora MendoncaTejasvini BhuvanNatalie L. PayneDi ZhengAssifa HisanaGeorgia WallisAdele BarugahareDavid PowellJai RautelaNicholas D. HuntingtonGrant DewsonDavid C. S. HuangDaniel H. D. GrayTracy S. P. HengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Swee Heng Milon Pang Joshua D’Rozario Senora Mendonca Tejasvini Bhuvan Natalie L. Payne Di Zheng Assifa Hisana Georgia Wallis Adele Barugahare David Powell Jai Rautela Nicholas D. Huntington Grant Dewson David C. S. Huang Daniel H. D. Gray Tracy S. P. Heng Mesenchymal stromal cell apoptosis is required for their therapeutic function
description	Mesenchymal stromal cells (MSCs) demonstrate therapeutic benefits in multiple diseases, but the mechanisms remain unclear as infused MSCs do not persist in the body. Here, the authors show that MSC apoptosis is an important mechanistic element, as MSCs rendered genetically incapable of apoptosis lose their ability to ameliorate disease.
format	article
author	Swee Heng Milon Pang Joshua D’Rozario Senora Mendonca Tejasvini Bhuvan Natalie L. Payne Di Zheng Assifa Hisana Georgia Wallis Adele Barugahare David Powell Jai Rautela Nicholas D. Huntington Grant Dewson David C. S. Huang Daniel H. D. Gray Tracy S. P. Heng
author_facet	Swee Heng Milon Pang Joshua D’Rozario Senora Mendonca Tejasvini Bhuvan Natalie L. Payne Di Zheng Assifa Hisana Georgia Wallis Adele Barugahare David Powell Jai Rautela Nicholas D. Huntington Grant Dewson David C. S. Huang Daniel H. D. Gray Tracy S. P. Heng
author_sort	Swee Heng Milon Pang
title	Mesenchymal stromal cell apoptosis is required for their therapeutic function
title_short	Mesenchymal stromal cell apoptosis is required for their therapeutic function
title_full	Mesenchymal stromal cell apoptosis is required for their therapeutic function
title_fullStr	Mesenchymal stromal cell apoptosis is required for their therapeutic function
title_full_unstemmed	Mesenchymal stromal cell apoptosis is required for their therapeutic function
title_sort	mesenchymal stromal cell apoptosis is required for their therapeutic function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/301d7cf4f8394cb5843dbd85fe61a7dd
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Mesenchymal stromal cell apoptosis is required for their therapeutic function

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