Mesenchymal stromal cell apoptosis is required for their therapeutic function
Mesenchymal stromal cells (MSCs) demonstrate therapeutic benefits in multiple diseases, but the mechanisms remain unclear as infused MSCs do not persist in the body. Here, the authors show that MSC apoptosis is an important mechanistic element, as MSCs rendered genetically incapable of apoptosis los...
Enregistré dans:
Auteurs principaux: | Swee Heng Milon Pang, Joshua D’Rozario, Senora Mendonca, Tejasvini Bhuvan, Natalie L. Payne, Di Zheng, Assifa Hisana, Georgia Wallis, Adele Barugahare, David Powell, Jai Rautela, Nicholas D. Huntington, Grant Dewson, David C. S. Huang, Daniel H. D. Gray, Tracy S. P. Heng |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/301d7cf4f8394cb5843dbd85fe61a7dd |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Analysis of core genes for colorectal cancer prognosis based on immune and stromal scores
par: Yi Zhu, et autres
Publié: (2021) -
Investigating heterogeneities of live mesenchymal stromal cells using AI-based label-free imaging
par: Sara Imboden, et autres
Publié: (2021) -
The Epithelial and Stromal Immune Microenvironment in Gastric Cancer: A Comprehensive Analysis Reveals Prognostic Factors with Digital Cytometry
par: Wenjun Shen, et autres
Publié: (2021) -
Stromal PTEN determines mammary epithelial response to radiotherapy
par: Gina M. Sizemore, et autres
Publié: (2018) -
Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus
par: Mario Nubile, et autres
Publié: (2021)