Mesenchymal stromal cell apoptosis is required for their therapeutic function

Mesenchymal stromal cell apoptosis is required for their therapeutic function

Mesenchymal stromal cells (MSCs) demonstrate therapeutic benefits in multiple diseases, but the mechanisms remain unclear as infused MSCs do not persist in the body. Here, the authors show that MSC apoptosis is an important mechanistic element, as MSCs rendered genetically incapable of apoptosis los...

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Bibliographic Details
Main Authors: Swee Heng Milon Pang, Joshua D’Rozario, Senora Mendonca, Tejasvini Bhuvan, Natalie L. Payne, Di Zheng, Assifa Hisana, Georgia Wallis, Adele Barugahare, David Powell, Jai Rautela, Nicholas D. Huntington, Grant Dewson, David C. S. Huang, Daniel H. D. Gray, Tracy S. P. Heng
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/301d7cf4f8394cb5843dbd85fe61a7dd
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