Dual extraction of essential oil and podophyllotoxin from creeping juniper (Juniperus horizontalis).

Juniperus horizontalis Moench (Family Cupressaceae), commonly called creeping juniper, is a widely distributed species in the United States and much of Canada. It is potentially a source for two important chemical products, the anticancer drug synthetic precursor, podophyllotoxin and essential oils....

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Autores principales:	Charles L Cantrell, Valtcho D Zheljazkov, Camila R Carvalho, Tess Astatkie, Ekaterina A Jeliazkova, Luiz H Rosa
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/301e52cdf83d4640bb1e30bd3eab69ed
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spelling	oai:doaj.org-article:301e52cdf83d4640bb1e30bd3eab69ed2021-11-25T06:01:19ZDual extraction of essential oil and podophyllotoxin from creeping juniper (Juniperus horizontalis).1932-620310.1371/journal.pone.0106057https://doaj.org/article/301e52cdf83d4640bb1e30bd3eab69ed2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0106057https://doaj.org/toc/1932-6203Juniperus horizontalis Moench (Family Cupressaceae), commonly called creeping juniper, is a widely distributed species in the United States and much of Canada. It is potentially a source for two important chemical products, the anticancer drug synthetic precursor, podophyllotoxin and essential oils. The objectives of this study were to ascertain the likelihood of utilizing J. horizontalis needles for the simultaneous production of both (-)-podophyllotoxin and essential oil components and to determine the optimum distillation time (DT) needed for the production of essential oil containing a specific ratio of constituents. Eleven different distillation times were tested in this study: 20, 40, 80, 160, 180, 240, 480, 600, 720, 840, and 960 min. Total essential oil content increased with increasing distillation time from a minimum of 0.023% at 20 min to a maximum of 1.098% at 960 min. The major constituents present in the oil were alpha-pinene, sabinene, and limonene. The percent concentration of sabinene in the essential oil varied from a high of 46.6% at 80 min to a low of 30.2% at 960 min, that of limonene changed very little as a result of distillation time and remained near 30% for all distillation times, whereas the concentration of alpha-pinene was 9.6% at 20 min DT and decreased to 4.2% at 960 min. Post distillation analysis of needles revealed elevated amounts of (-)-podophyllotoxin remaining in the tissue varied in the amount of podophyllotoxin present, from a low of 0.281% to a high of 0.364% as compared to undistilled needles which gave 0.217% podophyllotoxin. As a result of this study, specific essential oil components can now be targeted in J. horizontalis by varying the distillation time. Furthermore, needles can be successfully utilized as a source of both essential oil and podophyllotoxin, consecutively.Charles L CantrellValtcho D ZheljazkovCamila R CarvalhoTess AstatkieEkaterina A JeliazkovaLuiz H RosaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e106057 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Charles L Cantrell Valtcho D Zheljazkov Camila R Carvalho Tess Astatkie Ekaterina A Jeliazkova Luiz H Rosa Dual extraction of essential oil and podophyllotoxin from creeping juniper (Juniperus horizontalis).
description	Juniperus horizontalis Moench (Family Cupressaceae), commonly called creeping juniper, is a widely distributed species in the United States and much of Canada. It is potentially a source for two important chemical products, the anticancer drug synthetic precursor, podophyllotoxin and essential oils. The objectives of this study were to ascertain the likelihood of utilizing J. horizontalis needles for the simultaneous production of both (-)-podophyllotoxin and essential oil components and to determine the optimum distillation time (DT) needed for the production of essential oil containing a specific ratio of constituents. Eleven different distillation times were tested in this study: 20, 40, 80, 160, 180, 240, 480, 600, 720, 840, and 960 min. Total essential oil content increased with increasing distillation time from a minimum of 0.023% at 20 min to a maximum of 1.098% at 960 min. The major constituents present in the oil were alpha-pinene, sabinene, and limonene. The percent concentration of sabinene in the essential oil varied from a high of 46.6% at 80 min to a low of 30.2% at 960 min, that of limonene changed very little as a result of distillation time and remained near 30% for all distillation times, whereas the concentration of alpha-pinene was 9.6% at 20 min DT and decreased to 4.2% at 960 min. Post distillation analysis of needles revealed elevated amounts of (-)-podophyllotoxin remaining in the tissue varied in the amount of podophyllotoxin present, from a low of 0.281% to a high of 0.364% as compared to undistilled needles which gave 0.217% podophyllotoxin. As a result of this study, specific essential oil components can now be targeted in J. horizontalis by varying the distillation time. Furthermore, needles can be successfully utilized as a source of both essential oil and podophyllotoxin, consecutively.
format	article
author	Charles L Cantrell Valtcho D Zheljazkov Camila R Carvalho Tess Astatkie Ekaterina A Jeliazkova Luiz H Rosa
author_facet	Charles L Cantrell Valtcho D Zheljazkov Camila R Carvalho Tess Astatkie Ekaterina A Jeliazkova Luiz H Rosa
author_sort	Charles L Cantrell
title	Dual extraction of essential oil and podophyllotoxin from creeping juniper (Juniperus horizontalis).
title_short	Dual extraction of essential oil and podophyllotoxin from creeping juniper (Juniperus horizontalis).
title_full	Dual extraction of essential oil and podophyllotoxin from creeping juniper (Juniperus horizontalis).
title_fullStr	Dual extraction of essential oil and podophyllotoxin from creeping juniper (Juniperus horizontalis).
title_full_unstemmed	Dual extraction of essential oil and podophyllotoxin from creeping juniper (Juniperus horizontalis).
title_sort	dual extraction of essential oil and podophyllotoxin from creeping juniper (juniperus horizontalis).
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/301e52cdf83d4640bb1e30bd3eab69ed
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Dual extraction of essential oil and podophyllotoxin from creeping juniper (Juniperus horizontalis).

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