External ears for non-invasive and stable monitoring of volatile organic compounds in human blood

Abstract Volatile organic compounds (VOCs) released through skin (transcutaneous gas) has been increasing in importance for the continuous and real-time assessment of diseases or metabolisms. For stable monitoring of transcutaneous gas, finding a body part with little interference on the measurement...

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Autores principales:	Koji Toma, Shota Suzuki, Takahiro Arakawa, Yasuhiko Iwasaki, Kohji Mitsubayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/302064baa19348bc824554419feb3989
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spelling	oai:doaj.org-article:302064baa19348bc824554419feb39892021-12-02T17:47:04ZExternal ears for non-invasive and stable monitoring of volatile organic compounds in human blood10.1038/s41598-021-90146-12045-2322https://doaj.org/article/302064baa19348bc824554419feb39892021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90146-1https://doaj.org/toc/2045-2322Abstract Volatile organic compounds (VOCs) released through skin (transcutaneous gas) has been increasing in importance for the continuous and real-time assessment of diseases or metabolisms. For stable monitoring of transcutaneous gas, finding a body part with little interference on the measurement is essential. In this study, we have investigated the possibility of external ears for stable and real-time measurement of ethanol vapour by developing a monitoring system that consisted with an over-ear gas collection cell and a biochemical gas sensor (bio-sniffer). The high sensitivity with the broad dynamic range (26 ppb–554 ppm), the high selectivity to ethanol, and the capability of the continuous measurement of the monitoring system uncovered three important characteristics of external ear-derived ethanol with alcohol intake for the first time: there is little interference from sweat glands to a sensor signal at the external ear; similar temporal change in ethanol concentration to that of breath with delayed peak time (avg. 13 min); relatively high concentration of ethanol relative to other parts of a body (external ear-derived ethanol:breath ethanol = 1:590). These features indicated the suitability of external ears for non-invasive monitoring of blood VOCs.Koji TomaShota SuzukiTakahiro ArakawaYasuhiko IwasakiKohji MitsubayashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Koji Toma Shota Suzuki Takahiro Arakawa Yasuhiko Iwasaki Kohji Mitsubayashi External ears for non-invasive and stable monitoring of volatile organic compounds in human blood
description	Abstract Volatile organic compounds (VOCs) released through skin (transcutaneous gas) has been increasing in importance for the continuous and real-time assessment of diseases or metabolisms. For stable monitoring of transcutaneous gas, finding a body part with little interference on the measurement is essential. In this study, we have investigated the possibility of external ears for stable and real-time measurement of ethanol vapour by developing a monitoring system that consisted with an over-ear gas collection cell and a biochemical gas sensor (bio-sniffer). The high sensitivity with the broad dynamic range (26 ppb–554 ppm), the high selectivity to ethanol, and the capability of the continuous measurement of the monitoring system uncovered three important characteristics of external ear-derived ethanol with alcohol intake for the first time: there is little interference from sweat glands to a sensor signal at the external ear; similar temporal change in ethanol concentration to that of breath with delayed peak time (avg. 13 min); relatively high concentration of ethanol relative to other parts of a body (external ear-derived ethanol:breath ethanol = 1:590). These features indicated the suitability of external ears for non-invasive monitoring of blood VOCs.
format	article
author	Koji Toma Shota Suzuki Takahiro Arakawa Yasuhiko Iwasaki Kohji Mitsubayashi
author_facet	Koji Toma Shota Suzuki Takahiro Arakawa Yasuhiko Iwasaki Kohji Mitsubayashi
author_sort	Koji Toma
title	External ears for non-invasive and stable monitoring of volatile organic compounds in human blood
title_short	External ears for non-invasive and stable monitoring of volatile organic compounds in human blood
title_full	External ears for non-invasive and stable monitoring of volatile organic compounds in human blood
title_fullStr	External ears for non-invasive and stable monitoring of volatile organic compounds in human blood
title_full_unstemmed	External ears for non-invasive and stable monitoring of volatile organic compounds in human blood
title_sort	external ears for non-invasive and stable monitoring of volatile organic compounds in human blood
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/302064baa19348bc824554419feb3989
work_keys_str_mv	AT kojitoma externalearsfornoninvasiveandstablemonitoringofvolatileorganiccompoundsinhumanblood AT shotasuzuki externalearsfornoninvasiveandstablemonitoringofvolatileorganiccompoundsinhumanblood AT takahiroarakawa externalearsfornoninvasiveandstablemonitoringofvolatileorganiccompoundsinhumanblood AT yasuhikoiwasaki externalearsfornoninvasiveandstablemonitoringofvolatileorganiccompoundsinhumanblood AT kohjimitsubayashi externalearsfornoninvasiveandstablemonitoringofvolatileorganiccompoundsinhumanblood
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External ears for non-invasive and stable monitoring of volatile organic compounds in human blood

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