Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase

For developmental processes, we know most of the gene networks controlling specific cell responses. We still have to determine how these networks cooperate and how signals become integrated. The JNK pathway is one of the key elements modulating cellular responses during development. Yet, we still kn...

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Autores principales:	Katerina Karkali, Enrique Martin-Blanco
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	JNK <i>Drosophila</i> dual specificity phosphatase gene expression Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/3022ff5094b54c4aaee2b447191d2107
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id	oai:doaj.org-article:3022ff5094b54c4aaee2b447191d2107
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spelling	oai:doaj.org-article:3022ff5094b54c4aaee2b447191d21072021-11-25T17:54:20ZDissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase10.3390/ijms2222122051422-00671661-6596https://doaj.org/article/3022ff5094b54c4aaee2b447191d21072021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12205https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067For developmental processes, we know most of the gene networks controlling specific cell responses. We still have to determine how these networks cooperate and how signals become integrated. The JNK pathway is one of the key elements modulating cellular responses during development. Yet, we still know little about how the core components of the pathway interact with additional regulators or how this network modulates cellular responses in the whole organism in homeostasis or during tissue morphogenesis. We have performed a promoter analysis, searching for potential regulatory sequences of <i>puckered (puc)</i> and identified different specific enhancers directing gene expression in different tissues and at different developmental times. Remarkably, some of these domains respond to the JNK activity, but not all. Altogether, these analyses show that <i>puc</i> expression regulation is very complex and that JNK activities participate in non-previously known processes during the development of <i>Drosophila</i>.Katerina KarkaliEnrique Martin-BlancoMDPI AGarticleJNK<i>Drosophila</i>dual specificity phosphatasegene expressionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12205, p 12205 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	JNK <i>Drosophila</i> dual specificity phosphatase gene expression Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	JNK <i>Drosophila</i> dual specificity phosphatase gene expression Biology (General) QH301-705.5 Chemistry QD1-999 Katerina Karkali Enrique Martin-Blanco Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase
description	For developmental processes, we know most of the gene networks controlling specific cell responses. We still have to determine how these networks cooperate and how signals become integrated. The JNK pathway is one of the key elements modulating cellular responses during development. Yet, we still know little about how the core components of the pathway interact with additional regulators or how this network modulates cellular responses in the whole organism in homeostasis or during tissue morphogenesis. We have performed a promoter analysis, searching for potential regulatory sequences of <i>puckered (puc)</i> and identified different specific enhancers directing gene expression in different tissues and at different developmental times. Remarkably, some of these domains respond to the JNK activity, but not all. Altogether, these analyses show that <i>puc</i> expression regulation is very complex and that JNK activities participate in non-previously known processes during the development of <i>Drosophila</i>.
format	article
author	Katerina Karkali Enrique Martin-Blanco
author_facet	Katerina Karkali Enrique Martin-Blanco
author_sort	Katerina Karkali
title	Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase
title_short	Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase
title_full	Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase
title_fullStr	Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase
title_full_unstemmed	Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase
title_sort	dissection of the regulatory elements of the complex expression pattern of puckered, a dual-specificity jnk phosphatase
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3022ff5094b54c4aaee2b447191d2107
work_keys_str_mv	AT katerinakarkali dissectionoftheregulatoryelementsofthecomplexexpressionpatternofpuckeredadualspecificityjnkphosphatase AT enriquemartinblanco dissectionoftheregulatoryelementsofthecomplexexpressionpatternofpuckeredadualspecificityjnkphosphatase
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Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase

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