Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Galactomannan as a Model

ABSTRACT Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct s...

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Autores principales:	Sarah Sze Wah Wong, Vadim B. Krylov, Dmitry A. Argunov, Alexander A. Karelin, Jean-Phillipe Bouchara, Thierry Fontaine, Jean-Paul Latgé, Nikolay E. Nifantiev
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Aspergillus fumigatus aspergillosis antibodies cytokines chemokines immunology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/30257f6a3e5446a7a4bbca72295d39d2
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spelling	oai:doaj.org-article:30257f6a3e5446a7a4bbca72295d39d22021-11-15T15:27:52ZPotential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Galactomannan as a Model10.1128/mSphere.00688-192379-5042https://doaj.org/article/30257f6a3e5446a7a4bbca72295d39d22020-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00688-19https://doaj.org/toc/2379-5042ABSTRACT Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct structures representing key fragments of cell wall polysaccharides are the most precise tools to study the serological and immunomodulatory properties of a fungal polysaccharide.Sarah Sze Wah WongVadim B. KrylovDmitry A. ArgunovAlexander A. KarelinJean-Phillipe BoucharaThierry FontaineJean-Paul LatgéNikolay E. NifantievAmerican Society for MicrobiologyarticleAspergillus fumigatusaspergillosisantibodiescytokineschemokinesimmunologyMicrobiologyQR1-502ENmSphere, Vol 5, Iss 1 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aspergillus fumigatus aspergillosis antibodies cytokines chemokines immunology Microbiology QR1-502
spellingShingle	Aspergillus fumigatus aspergillosis antibodies cytokines chemokines immunology Microbiology QR1-502 Sarah Sze Wah Wong Vadim B. Krylov Dmitry A. Argunov Alexander A. Karelin Jean-Phillipe Bouchara Thierry Fontaine Jean-Paul Latgé Nikolay E. Nifantiev Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Galactomannan as a Model
description	ABSTRACT Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct structures representing key fragments of cell wall polysaccharides are the most precise tools to study the serological and immunomodulatory properties of a fungal polysaccharide.
format	article
author	Sarah Sze Wah Wong Vadim B. Krylov Dmitry A. Argunov Alexander A. Karelin Jean-Phillipe Bouchara Thierry Fontaine Jean-Paul Latgé Nikolay E. Nifantiev
author_facet	Sarah Sze Wah Wong Vadim B. Krylov Dmitry A. Argunov Alexander A. Karelin Jean-Phillipe Bouchara Thierry Fontaine Jean-Paul Latgé Nikolay E. Nifantiev
author_sort	Sarah Sze Wah Wong
title	Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Galactomannan as a Model
title_short	Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Galactomannan as a Model
title_full	Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Galactomannan as a Model
title_fullStr	Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Galactomannan as a Model
title_full_unstemmed	Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Galactomannan as a Model
title_sort	potential of chemically synthesized oligosaccharides to define the carbohydrate moieties of the fungal cell wall responsible for the human immune response, using <named-content content-type="genus-species">aspergillus fumigatus</named-content> galactomannan as a model
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/30257f6a3e5446a7a4bbca72295d39d2
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Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using <named-content content-type="genus-species">Aspergillus fumigatus</named-content> Galactomannan as a Model

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