Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin

Titin is considered an integrator of muscle cell proteins but direct evidence is limited. Here, titin is inactivated in adult mouse muscles, which causes sarcomere disassembly, protein mis-expression and force impairment, recapitulating key alterations in critical illness myopathy patient muscles.

Guardado en:

Detalles Bibliográficos
Autores principales:	Sandra Swist, Andreas Unger, Yong Li, Anja Vöge, Marion von Frieling-Salewsky, Åsa Skärlén, Nicola Cacciani, Thomas Braun, Lars Larsson, Wolfgang A. Linke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/302edbcae576463d8910dcb3be630c60
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:302edbcae576463d8910dcb3be630c60
record_format	dspace
spelling	oai:doaj.org-article:302edbcae576463d8910dcb3be630c602021-12-02T19:13:48ZMaintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin10.1038/s41467-020-18131-22041-1723https://doaj.org/article/302edbcae576463d8910dcb3be630c602020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18131-2https://doaj.org/toc/2041-1723Titin is considered an integrator of muscle cell proteins but direct evidence is limited. Here, titin is inactivated in adult mouse muscles, which causes sarcomere disassembly, protein mis-expression and force impairment, recapitulating key alterations in critical illness myopathy patient muscles.Sandra SwistAndreas UngerYong LiAnja VögeMarion von Frieling-SalewskyÅsa SkärlénNicola CaccianiThomas BraunLars LarssonWolfgang A. LinkeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sandra Swist Andreas Unger Yong Li Anja Vöge Marion von Frieling-Salewsky Åsa Skärlén Nicola Cacciani Thomas Braun Lars Larsson Wolfgang A. Linke Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
description	Titin is considered an integrator of muscle cell proteins but direct evidence is limited. Here, titin is inactivated in adult mouse muscles, which causes sarcomere disassembly, protein mis-expression and force impairment, recapitulating key alterations in critical illness myopathy patient muscles.
format	article
author	Sandra Swist Andreas Unger Yong Li Anja Vöge Marion von Frieling-Salewsky Åsa Skärlén Nicola Cacciani Thomas Braun Lars Larsson Wolfgang A. Linke
author_facet	Sandra Swist Andreas Unger Yong Li Anja Vöge Marion von Frieling-Salewsky Åsa Skärlén Nicola Cacciani Thomas Braun Lars Larsson Wolfgang A. Linke
author_sort	Sandra Swist
title	Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
title_short	Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
title_full	Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
title_fullStr	Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
title_full_unstemmed	Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
title_sort	maintenance of sarcomeric integrity in adult muscle cells crucially depends on z-disc anchored titin
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/302edbcae576463d8910dcb3be630c60
work_keys_str_mv	AT sandraswist maintenanceofsarcomericintegrityinadultmusclecellscruciallydependsonzdiscanchoredtitin AT andreasunger maintenanceofsarcomericintegrityinadultmusclecellscruciallydependsonzdiscanchoredtitin AT yongli maintenanceofsarcomericintegrityinadultmusclecellscruciallydependsonzdiscanchoredtitin AT anjavoge maintenanceofsarcomericintegrityinadultmusclecellscruciallydependsonzdiscanchoredtitin AT marionvonfrielingsalewsky maintenanceofsarcomericintegrityinadultmusclecellscruciallydependsonzdiscanchoredtitin AT asaskarlen maintenanceofsarcomericintegrityinadultmusclecellscruciallydependsonzdiscanchoredtitin AT nicolacacciani maintenanceofsarcomericintegrityinadultmusclecellscruciallydependsonzdiscanchoredtitin AT thomasbraun maintenanceofsarcomericintegrityinadultmusclecellscruciallydependsonzdiscanchoredtitin AT larslarsson maintenanceofsarcomericintegrityinadultmusclecellscruciallydependsonzdiscanchoredtitin AT wolfgangalinke maintenanceofsarcomericintegrityinadultmusclecellscruciallydependsonzdiscanchoredtitin
_version_	1718377013183512576

Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin

Ejemplares similares