DNA methylation predicts age and provides insight into exceptional longevity of bats
DNA methylation profiles from 26 bat species accurately predicts chronological age, while longevity-related methylation patterns across the genome suggest that bat longevity results from augmented immune response and cancer suppression.
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Nature Portfolio
2021
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oai:doaj.org-article:30303b45b1804d76a4024dd8d7b209d32021-12-02T11:36:20ZDNA methylation predicts age and provides insight into exceptional longevity of bats10.1038/s41467-021-21900-22041-1723https://doaj.org/article/30303b45b1804d76a4024dd8d7b209d32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21900-2https://doaj.org/toc/2041-1723DNA methylation profiles from 26 bat species accurately predicts chronological age, while longevity-related methylation patterns across the genome suggest that bat longevity results from augmented immune response and cancer suppression.Gerald S. WilkinsonDanielle M. AdamsAmin HaghaniAke T. LuJoseph ZollerCharles E. BreezeBryan D. ArnoldHope C. BallGerald G. CarterLisa Noelle CooperDina K. N. DechmannPaolo DevannaNicolas J. FaselAlexander V. GalazyukLinus GüntherEdward HurmeGareth JonesMirjam KnörnschildElla Z. LattenkampCaesar Z. LiFrieder MayerJosephine A. ReinhardtRodrigo A. MedellinMartina NagyBrian PopeMegan L. PowerRoger D. RansomeEmma C. TeelingSonja C. VernesDaniel Zamora-MejíasJoshua ZhangPaul A. FaureLucas J. GrevilleSteve HorvathNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q Gerald S. Wilkinson Danielle M. Adams Amin Haghani Ake T. Lu Joseph Zoller Charles E. Breeze Bryan D. Arnold Hope C. Ball Gerald G. Carter Lisa Noelle Cooper Dina K. N. Dechmann Paolo Devanna Nicolas J. Fasel Alexander V. Galazyuk Linus Günther Edward Hurme Gareth Jones Mirjam Knörnschild Ella Z. Lattenkamp Caesar Z. Li Frieder Mayer Josephine A. Reinhardt Rodrigo A. Medellin Martina Nagy Brian Pope Megan L. Power Roger D. Ransome Emma C. Teeling Sonja C. Vernes Daniel Zamora-Mejías Joshua Zhang Paul A. Faure Lucas J. Greville Steve Horvath DNA methylation predicts age and provides insight into exceptional longevity of bats |
| description |
DNA methylation profiles from 26 bat species accurately predicts chronological age, while longevity-related methylation patterns across the genome suggest that bat longevity results from augmented immune response and cancer suppression. |
| format |
article |
| author |
Gerald S. Wilkinson Danielle M. Adams Amin Haghani Ake T. Lu Joseph Zoller Charles E. Breeze Bryan D. Arnold Hope C. Ball Gerald G. Carter Lisa Noelle Cooper Dina K. N. Dechmann Paolo Devanna Nicolas J. Fasel Alexander V. Galazyuk Linus Günther Edward Hurme Gareth Jones Mirjam Knörnschild Ella Z. Lattenkamp Caesar Z. Li Frieder Mayer Josephine A. Reinhardt Rodrigo A. Medellin Martina Nagy Brian Pope Megan L. Power Roger D. Ransome Emma C. Teeling Sonja C. Vernes Daniel Zamora-Mejías Joshua Zhang Paul A. Faure Lucas J. Greville Steve Horvath |
| author_facet |
Gerald S. Wilkinson Danielle M. Adams Amin Haghani Ake T. Lu Joseph Zoller Charles E. Breeze Bryan D. Arnold Hope C. Ball Gerald G. Carter Lisa Noelle Cooper Dina K. N. Dechmann Paolo Devanna Nicolas J. Fasel Alexander V. Galazyuk Linus Günther Edward Hurme Gareth Jones Mirjam Knörnschild Ella Z. Lattenkamp Caesar Z. Li Frieder Mayer Josephine A. Reinhardt Rodrigo A. Medellin Martina Nagy Brian Pope Megan L. Power Roger D. Ransome Emma C. Teeling Sonja C. Vernes Daniel Zamora-Mejías Joshua Zhang Paul A. Faure Lucas J. Greville Steve Horvath |
| author_sort |
Gerald S. Wilkinson |
| title |
DNA methylation predicts age and provides insight into exceptional longevity of bats |
| title_short |
DNA methylation predicts age and provides insight into exceptional longevity of bats |
| title_full |
DNA methylation predicts age and provides insight into exceptional longevity of bats |
| title_fullStr |
DNA methylation predicts age and provides insight into exceptional longevity of bats |
| title_full_unstemmed |
DNA methylation predicts age and provides insight into exceptional longevity of bats |
| title_sort |
dna methylation predicts age and provides insight into exceptional longevity of bats |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/30303b45b1804d76a4024dd8d7b209d3 |
| work_keys_str_mv |
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