INTERACTIONS OF PATHOGENIC BACTERIA WITH INNATE IMMUNE REACTIONS OF HOST

Abstract. «Efficacy» of pathogens interaction with the immunity system is manifested by broad spreading of many bacterial infections including tuberculosis first of all and in activation of known and emergent pathogens. The refined mechanisms of avoiding of bacteria from recognizing by immune system...

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Autores principales:	F. Yu. Garib, A. P. Rizopulu
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	bacterial evasion inflammation phagocytosis antigen presentation Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/3032820d0d1c457b8e5f2ae621dbbf9d
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spelling	oai:doaj.org-article:3032820d0d1c457b8e5f2ae621dbbf9d2021-11-22T07:09:45ZINTERACTIONS OF PATHOGENIC BACTERIA WITH INNATE IMMUNE REACTIONS OF HOST2220-76192313-739810.15789/2220-7619-2012-3-581-596https://doaj.org/article/3032820d0d1c457b8e5f2ae621dbbf9d2014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/74https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. «Efficacy» of pathogens interaction with the immunity system is manifested by broad spreading of many bacterial infections including tuberculosis first of all and in activation of known and emergent pathogens. The refined mechanisms of avoiding of bacteria from recognizing by immune system as creation of obstacles for phagocytosis and intracellular killing, using of secretory systems like “syringe” for inoculation into host cells deregulated substances, suppression or enhancing of inflammatory response, activation of inhibitory receptors to suppress respiratory explosion in phagosome, decreasing of synthesis of proinflammatory cytokines by influences to inflammasomes, stimulation of cytokines production suppres sed of innate response, damage of key molecules on intracellular signal routes, manipulation with apoptosis and auto phagia with the aim of surviving and replication inside the host cells, blocking of processing and presentation of bacterial antigens have been evolutionary developed. The study of interaction between host and parasite allows to understand new facts characterized “logic of live being” on the pathogen level and to use their mechanisms of evasion for resolving of actual problems raised in human society, for example, development of original vaccines and principally new drugs for immune system correction in case of diseases such as oncogenic tumors, autoimmune and allergic diseases as well as infectious diseases which are difficult to prevent and treat. Moreover, it was proved that permanent interaction with microorganisms including pathogenic ones is useful for human being because bacterial substances “train” immune system of people and assist its evolutionary improvement.F. Yu. GaribA. P. RizopuluSankt-Peterburg : NIIÈM imeni Pasteraarticlebacterial evasioninflammationphagocytosisantigen presentationInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 2, Iss 3, Pp 581-596 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	bacterial evasion inflammation phagocytosis antigen presentation Infectious and parasitic diseases RC109-216
spellingShingle	bacterial evasion inflammation phagocytosis antigen presentation Infectious and parasitic diseases RC109-216 F. Yu. Garib A. P. Rizopulu INTERACTIONS OF PATHOGENIC BACTERIA WITH INNATE IMMUNE REACTIONS OF HOST
description	Abstract. «Efficacy» of pathogens interaction with the immunity system is manifested by broad spreading of many bacterial infections including tuberculosis first of all and in activation of known and emergent pathogens. The refined mechanisms of avoiding of bacteria from recognizing by immune system as creation of obstacles for phagocytosis and intracellular killing, using of secretory systems like “syringe” for inoculation into host cells deregulated substances, suppression or enhancing of inflammatory response, activation of inhibitory receptors to suppress respiratory explosion in phagosome, decreasing of synthesis of proinflammatory cytokines by influences to inflammasomes, stimulation of cytokines production suppres sed of innate response, damage of key molecules on intracellular signal routes, manipulation with apoptosis and auto phagia with the aim of surviving and replication inside the host cells, blocking of processing and presentation of bacterial antigens have been evolutionary developed. The study of interaction between host and parasite allows to understand new facts characterized “logic of live being” on the pathogen level and to use their mechanisms of evasion for resolving of actual problems raised in human society, for example, development of original vaccines and principally new drugs for immune system correction in case of diseases such as oncogenic tumors, autoimmune and allergic diseases as well as infectious diseases which are difficult to prevent and treat. Moreover, it was proved that permanent interaction with microorganisms including pathogenic ones is useful for human being because bacterial substances “train” immune system of people and assist its evolutionary improvement.
format	article
author	F. Yu. Garib A. P. Rizopulu
author_facet	F. Yu. Garib A. P. Rizopulu
author_sort	F. Yu. Garib
title	INTERACTIONS OF PATHOGENIC BACTERIA WITH INNATE IMMUNE REACTIONS OF HOST
title_short	INTERACTIONS OF PATHOGENIC BACTERIA WITH INNATE IMMUNE REACTIONS OF HOST
title_full	INTERACTIONS OF PATHOGENIC BACTERIA WITH INNATE IMMUNE REACTIONS OF HOST
title_fullStr	INTERACTIONS OF PATHOGENIC BACTERIA WITH INNATE IMMUNE REACTIONS OF HOST
title_full_unstemmed	INTERACTIONS OF PATHOGENIC BACTERIA WITH INNATE IMMUNE REACTIONS OF HOST
title_sort	interactions of pathogenic bacteria with innate immune reactions of host
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/3032820d0d1c457b8e5f2ae621dbbf9d
work_keys_str_mv	AT fyugarib interactionsofpathogenicbacteriawithinnateimmunereactionsofhost AT aprizopulu interactionsofpathogenicbacteriawithinnateimmunereactionsofhost
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INTERACTIONS OF PATHOGENIC BACTERIA WITH INNATE IMMUNE REACTIONS OF HOST

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