Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines

Benzofluorene-containing angucyclines, bacterial natural compounds with potential use as therapeutics/antibiotics, occur as dimers. Here, the authors elucidated the dimerization mechanism which turned out to work spontaneously, without enzymatic catalysis.

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Autores principales:	Chunshuai Huang, Chunfang Yang, Wenjun Zhang, Liping Zhang, Bidhan Chandra De, Yiguang Zhu, Xiaodong Jiang, Chunyan Fang, Qingbo Zhang, Cheng-Shan Yuan, Hung-wen Liu, Changsheng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30344ff8e3c44b39b61e7fdaf8585390
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spelling	oai:doaj.org-article:30344ff8e3c44b39b61e7fdaf85853902021-12-02T16:49:48ZMolecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines10.1038/s41467-018-04487-z2041-1723https://doaj.org/article/30344ff8e3c44b39b61e7fdaf85853902018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04487-zhttps://doaj.org/toc/2041-1723Benzofluorene-containing angucyclines, bacterial natural compounds with potential use as therapeutics/antibiotics, occur as dimers. Here, the authors elucidated the dimerization mechanism which turned out to work spontaneously, without enzymatic catalysis.Chunshuai HuangChunfang YangWenjun ZhangLiping ZhangBidhan Chandra DeYiguang ZhuXiaodong JiangChunyan FangQingbo ZhangCheng-Shan YuanHung-wen LiuChangsheng ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chunshuai Huang Chunfang Yang Wenjun Zhang Liping Zhang Bidhan Chandra De Yiguang Zhu Xiaodong Jiang Chunyan Fang Qingbo Zhang Cheng-Shan Yuan Hung-wen Liu Changsheng Zhang Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines
description	Benzofluorene-containing angucyclines, bacterial natural compounds with potential use as therapeutics/antibiotics, occur as dimers. Here, the authors elucidated the dimerization mechanism which turned out to work spontaneously, without enzymatic catalysis.
format	article
author	Chunshuai Huang Chunfang Yang Wenjun Zhang Liping Zhang Bidhan Chandra De Yiguang Zhu Xiaodong Jiang Chunyan Fang Qingbo Zhang Cheng-Shan Yuan Hung-wen Liu Changsheng Zhang
author_facet	Chunshuai Huang Chunfang Yang Wenjun Zhang Liping Zhang Bidhan Chandra De Yiguang Zhu Xiaodong Jiang Chunyan Fang Qingbo Zhang Cheng-Shan Yuan Hung-wen Liu Changsheng Zhang
author_sort	Chunshuai Huang
title	Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines
title_short	Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines
title_full	Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines
title_fullStr	Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines
title_full_unstemmed	Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines
title_sort	molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/30344ff8e3c44b39b61e7fdaf8585390
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Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines

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