Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells

The nuclear receptor Pparg regulates urothelial differentiation in vitro but its role in healthy urothelium is unclear. Here, the authors show that PPAR gamma mediates urothelial development during both homeostasis (via mitochondrial function) and following infection, via an inflammatory response.

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Autores principales:	Chang Liu, Tiffany Tate, Ekatherina Batourina, Steven T. Truschel, Steven Potter, Mike Adam, Tina Xiang, Martin Picard, Maia Reiley, Kerry Schneider, Manuel Tamargo, Chao Lu, Xiao Chen, Jing He, Hyunwoo Kim, Cathy Lee Mendelsohn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/303531835cbf4da28f7e0d26a90b094e
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spelling	oai:doaj.org-article:303531835cbf4da28f7e0d26a90b094e2021-12-02T14:35:50ZPparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells10.1038/s41467-019-12332-02041-1723https://doaj.org/article/303531835cbf4da28f7e0d26a90b094e2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12332-0https://doaj.org/toc/2041-1723The nuclear receptor Pparg regulates urothelial differentiation in vitro but its role in healthy urothelium is unclear. Here, the authors show that PPAR gamma mediates urothelial development during both homeostasis (via mitochondrial function) and following infection, via an inflammatory response.Chang LiuTiffany TateEkatherina BatourinaSteven T. TruschelSteven PotterMike AdamTina XiangMartin PicardMaia ReileyKerry SchneiderManuel TamargoChao LuXiao ChenJing HeHyunwoo KimCathy Lee MendelsohnNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chang Liu Tiffany Tate Ekatherina Batourina Steven T. Truschel Steven Potter Mike Adam Tina Xiang Martin Picard Maia Reiley Kerry Schneider Manuel Tamargo Chao Lu Xiao Chen Jing He Hyunwoo Kim Cathy Lee Mendelsohn Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
description	The nuclear receptor Pparg regulates urothelial differentiation in vitro but its role in healthy urothelium is unclear. Here, the authors show that PPAR gamma mediates urothelial development during both homeostasis (via mitochondrial function) and following infection, via an inflammatory response.
format	article
author	Chang Liu Tiffany Tate Ekatherina Batourina Steven T. Truschel Steven Potter Mike Adam Tina Xiang Martin Picard Maia Reiley Kerry Schneider Manuel Tamargo Chao Lu Xiao Chen Jing He Hyunwoo Kim Cathy Lee Mendelsohn
author_facet	Chang Liu Tiffany Tate Ekatherina Batourina Steven T. Truschel Steven Potter Mike Adam Tina Xiang Martin Picard Maia Reiley Kerry Schneider Manuel Tamargo Chao Lu Xiao Chen Jing He Hyunwoo Kim Cathy Lee Mendelsohn
author_sort	Chang Liu
title	Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
title_short	Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
title_full	Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
title_fullStr	Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
title_full_unstemmed	Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
title_sort	pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/303531835cbf4da28f7e0d26a90b094e
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Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells

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